Ashwagandha root extract sustained-release (AshwaSR) reduces perceived stress and improves sleep quality in healthy stressed adults
In a randomized, double-blind, placebo-controlled trial, AshwaSR 150 mg and 300 mg capsules significantly reduced Perceived Stress Scale scores by 38.6% and 41.6% respectively from baseline to day 60 (P < .001). Both doses also significantly improved sleep quality, psychological well-being, and eating behavior compared to placebo, with the 300 mg dose additionally reducing serum cortisol levels (P < .05).
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Ashwagandha root extract sustained-release (AshwaSR) reduces perceived stress and improves sleep quality in healthy stressed adults The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 42/100 (low).
The Claim
Ashwagandha root extract sustained-release (AshwaSR) reduces perceived stress and improves sleep quality in healthy stressed adults
This conclusion is most relevant to: Healthy adult stressed subjects with Perceived Stress Scale score 14 to 26, mean age 34.79 ± 8.16 years.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial. (Medicine, 2026) —
How It Works
The proposed biological pathway:
- ▸Ashwagandha root extract acts as an adaptogen
- ▸Sustained-release formulation provides prolonged exposure
- ▸Modulation of hypothalamic-pituitary-adrenal axis reduces cortisol levels
- ▸Result: Reduced perceived stress and improved sleep quality
Who Might Benefit
Evidence fit by population:
- ▸Healthy adult stressed subjects with Perceived Stress Scale score 14 to 26, mean age 34.79 ± 8.16 years
Recommended Dose
150 mg or 300 mg once daily
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Abstract does not report effect sizes or confidence intervals for sleep quality improvements
- ▸Short duration (60 days) limits assessment of long-term efficacy and safety
- ▸Single-center design may limit generalizability
Frequently Asked Questions
What is AshwaSR?▼
AshwaSR is a sustained-release formulation of Ashwagandha root extract, tested at 150 mg and 300 mg once daily.
How much did stress levels decrease in the study?▼
Perceived Stress Scale scores decreased by 38.6% in the 150 mg group and 41.6% in the 300 mg group over 60 days.
Did AshwaSR improve sleep quality?▼
Yes, both doses significantly improved sleep quality compared to placebo (P < .001).
Was the supplement safe?▼
No safety concerns were reported during the 60-day trial.
References
- 1.Thanawala S, Shah R, Alluri KV, Bhupathiraju K, Desomayanandanam P, Bhuvenendran A. “Efficacy and safety of Ashwagandha root extract sustained-release (AshwaSR) capsules in healthy adult, stressed subjects: A randomized, double-blind, placebo-controlled, parallel-group, 3-arm clinical trial..” Medicine, 2026. PMID: 41824889 DOI: 10.1097/MD.0000000000047990