Constituents of Passiflora incarnata inhibit OATP2B1 and OATP1A2 transporters, potentially affecting uptake of other compounds.
Apigenin, orientin, and vitexin from Passiflora incarnata inhibited OATP2B1 and OATP1A2-mediated uptake of sulfated steroids in vitro. Orientin was a substrate of both transporters, apigenin of OATP1A2, and vitexin of OATP2B1. Commercially available P. incarnata preparations also inhibited transporter-mediated uptake.
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Constituents of Passiflora incarnata inhibit OATP2B1 and OATP1A2 transporters, potentially affecting uptake of other compounds. The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
Constituents of Passiflora incarnata inhibit OATP2B1 and OATP1A2 transporters, potentially affecting uptake of other compounds.
This conclusion is most relevant to: Madin-Darby canine kidney cells overexpressing OATP2B1 or OATP1A2 (in vitro).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. (Planta medica, 2022) —
How It Works
The proposed biological pathway:
- ▸Apigenin, orientin, and vitexin interact with OATP2B1 and OATP1A2
- ▸Orientin is a substrate of both transporters
- ▸Apigenin is a substrate of OATP1A2, vitexin of OATP2B1
- ▸Result: Constituents of P. incarnata may alter function of OATP2B1 and OATP1A2, affecting uptake of other compounds
Who Might Benefit
Evidence fit by population:
- ▸Madin-Darby canine kidney cells overexpressing OATP2B1 or OATP1A2 (in vitro)
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸In vitro study using overexpressing cell lines may not reflect in vivo human physiology
- ▸Only sulfated steroids were tested as substrates; relevance to other compounds is unknown
Frequently Asked Questions
What are the main active compounds in Passiflora incarnata that affect transporters?▼
Apigenin, orientin, and vitexin were identified as interacting with OATP2B1 and OATP1A2.
Did valerenic acid from Valeriana officinalis interact with the transporters?▼
Valerenic acid only interacted with OATP2B1, not OATP1A2.
Could Passiflora incarnata supplements affect drug absorption?▼
Yes, the study suggests constituents may alter OATP transporter function, potentially affecting uptake of other compounds relying on these transporters.
What type of study was this?▼
This was an in vitro laboratory study using overexpressing cell lines, not a clinical trial.
References
- 1.Schäfer AM, Gilgen PM, Spirgi C, Potterat O, Meyer Zu Schwabedissen HE. “Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2..” Planta medica, 2022. PMID: 33511622 DOI: 10.1055/a-1305-3936