Endurance training attenuates acute exercise-induced monocyte transcriptomic responses in adolescents, with sex-specific molecular adaptations
In adolescents aged 14-17, an 8-week endurance training program markedly reduced the number of differentially expressed monocyte transcripts in response to acute exercise, from 5,135 to 94 in females (98% reduction) and from 567 to 165 in males (70% reduction). Pre-training, females showed a much larger transcriptomic response than males, with pathway enrichment related to adipose tissue crosstalk and oxidative metabolism, while males showed vascular function-related pathways.
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Endurance training attenuates acute exercise-induced monocyte transcriptomic responses in adolescents, with sex-specific molecular adaptations The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 32/100 (low).
The Claim
Endurance training attenuates acute exercise-induced monocyte transcriptomic responses in adolescents, with sex-specific molecular adaptations
This conclusion is most relevant to: Adolescents aged 14-17 years (12 males, 9 females).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Endurance Training Attenuates Acute Exercise-Induced Monocyte Transcriptomic Responses in Adolescents: Sex-Specific Molecular Adaptations. (Journal of applied physiology (Bethesda, Md. : 1985), 2026) —
How It Works
The proposed biological pathway:
- ▸Acute exercise induces changes in monocyte gene expression
- ▸Pre-training, females show a larger transcriptomic response than males
- ▸Endurance training reduces the magnitude of this response in both sexes
- ▸Result: Attenuated monocyte transcriptional responsiveness, potentially affecting vascular and cardiovascular health
Who Might Benefit
Evidence fit by population:
- ▸Adolescents aged 14-17 years (12 males, 9 females)
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Small sample size (n=21) limits generalizability
- ▸FDR threshold of 0.1 is less stringent than typical 0.05, potentially inflating the number of differentially expressed transcripts
Frequently Asked Questions
What was the main finding of the study?▼
The main finding was that 8 weeks of endurance training significantly reduced the monocyte transcriptomic response to acute exercise in adolescents, with a larger reduction in females (98%) compared to males (70%).
How did the monocyte response differ between sexes before training?▼
Before training, females had a much larger transcriptomic response (5,135 differentially expressed transcripts) compared to males (567), and the pathways involved were different, with females showing adipose tissue crosstalk and oxidative metabolism, and males showing vascular function-related pathways.
What does this imply for cardiovascular health?▼
The attenuation of monocyte transcriptional responsiveness after training may reflect improved immune regulation and reduced inflammatory potential, which could be beneficial for vascular health and reduce cardiovascular disease risk later in life.
What type of exercise was used in the training program?▼
The training program consisted of supervised endurance training with brief supplementary strength work, performed for 60 minutes per session, 3 sessions per week, over 8 weeks.
References
- 1.Plaza-Florido A, Haddad F, Cooper DM, Radom-Aizik S. “Endurance Training Attenuates Acute Exercise-Induced Monocyte Transcriptomic Responses in Adolescents: Sex-Specific Molecular Adaptations..” Journal of applied physiology (Bethesda, Md. : 1985), 2026. PMID: 42545855 DOI: 10.1152/japplphysiol.00282.2026