Fermented Gastrodia elata Bl. (FGE) attenuates pentylenetetrazole-induced sleep disturbances in zebrafish by modulating gut microbiota and amino acid metabolism to promote 5-HT homeostasis
FGE significantly attenuated PTZ-induced insomnia behavior, circadian rhythm disturbances, and compromised gut barrier functions in zebrafish. The study identified gut microbiota as a key mediator and amino acid metabolism as the central mechanistic pathway through which FGE promotes 5-HT homeostasis and protects against short-term sleep disturbances.
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Fermented Gastrodia elata Bl. (FGE) attenuates pentylenetetrazole-induced sleep disturbances in zebrafish by modulating gut microbiota and amino acid metabolism to promote 5-HT homeostasis The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
Fermented Gastrodia elata Bl. (FGE) attenuates pentylenetetrazole-induced sleep disturbances in zebrafish by modulating gut microbiota and amino acid metabolism to promote 5-HT homeostasis
This conclusion is most relevant to: Zebrafish with pentylenetetrazole (PTZ)-induced sleep disturbances.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Fermented Gastrodia elata Bl. Intervenes gut microbiota and amino acid metabolism in zebrafish to promote 5-HT homeostasis against sleep disturbances. (Food research international (Ottawa, Ont.), 2025) —
How It Works
The proposed biological pathway:
- ▸FGE modulates gut microbiota composition
- ▸FGE alters amino acid metabolism-related pathways
- ▸Remodeling of intestinal microbial structure and metabolites drives 5-HT homeostasis in different tissues
- ▸FGE attenuates PTZ-induced insomnia behavior and circadian rhythm disturbances
Who Might Benefit
Evidence fit by population:
- ▸Zebrafish with pentylenetetrazole (PTZ)-induced sleep disturbances
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Animal model (zebrafish) may not directly translate to human sleep disturbances
- ▸Short-term sleep disturbance model only, long-term effects not assessed
Frequently Asked Questions
What is Fermented Gastrodia elata Bl. (FGE)?▼
FGE is a fermented form of Gastrodia elata Bl., a traditional Chinese medicinal herb, used as a dietary supplement to prevent sleep disturbances.
How does FGE affect sleep in this study?▼
FGE attenuated pentylenetetrazole-induced insomnia behavior and circadian rhythm disturbances in zebrafish by modulating gut microbiota and amino acid metabolism to promote 5-HT homeostasis.
What is the role of gut microbiota in FGE's effect?▼
Gut microbiota was identified as a key mediator and potential therapeutic target for FGE, as shown by fecal microbiota transplantation experiments and 16S rRNA sequencing.
Is FGE safe for human use?▼
This study did not assess human safety; it was conducted in zebrafish. Further research is needed to evaluate safety and efficacy in humans.
References
- 1.Zhang C, Zhang X, Qiu H, Song Q, Wang Y, Zhang C, Zhang Q. “Fermented Gastrodia elata Bl. Intervenes gut microbiota and amino acid metabolism in zebrafish to promote 5-HT homeostasis against sleep disturbances..” Food research international (Ottawa, Ont.), 2025. PMID: 40597484 DOI: 10.1016/j.foodres.2025.116757