Ferula asafoetida oleo-gum resin (ASF) improves sleep quality in individuals with functional dyspepsia symptoms
In a randomized, double-blind, placebo-controlled trial, 62 participants with functional dyspepsia symptoms received 250 mg/day of ASF or placebo for 14 days. ASF treatment significantly improved sleep quality as measured by the Bergen Insomnia Scale, with a mean change of 10.89 ± 3.23 points (P < .001) on day 14.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Ferula asafoetida oleo-gum resin (ASF) improves sleep quality in individuals with functional dyspepsia symptoms The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 44/100 (low).
The Claim
Ferula asafoetida oleo-gum resin (ASF) improves sleep quality in individuals with functional dyspepsia symptoms
This conclusion is most relevant to: 62 participants diagnosed with functional dyspepsia symptoms.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Ferula asafoetida oleo-gum resin alleviates dyspepsia symptoms through modulation of microbiome-gut-brain axis: A randomized, double-blind, placebo-controlled study. (Medicine, 2025) —
How It Works
The proposed biological pathway:
- ▸ASF modulates gut microbiota by decreasing Firmicutes-to-Bacteroidetes ratio and enhancing alpha diversity
- ▸ASF enriches beneficial genera (e.g., Bacteroides, Prevotella) and reduces harmful taxa (e.g., Escherichia, Clostridia)
- ▸These microbiome changes influence the microbiome-gut-brain axis
- ▸Result: Improved sleep quality, reduced dyspepsia symptoms, and enhanced cognitive performance
Who Might Benefit
Evidence fit by population:
- ▸62 participants diagnosed with functional dyspepsia symptoms
Recommended Dose
250 mg/day
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Small sample size (n=62) limits generalizability
- ▸Short intervention duration (14 days) does not assess long-term efficacy or safety
Frequently Asked Questions
What is the Bergen Insomnia Scale and how was it used?▼
The Bergen Insomnia Scale (BIS) is a validated questionnaire assessing insomnia symptoms. In this study, it was used to measure sleep quality at baseline and on day 14, with a higher score indicating worse sleep.
How does Ferula asafoetida improve sleep?▼
The proposed mechanism involves modulation of the gut microbiome (reducing Firmicutes-to-Bacteroidetes ratio and increasing beneficial bacteria), which influences the microbiome-gut-brain axis, leading to improved sleep quality.
Is this study applicable to people without dyspepsia?▼
No, the study only included participants with functional dyspepsia symptoms, so the sleep improvement may not generalize to healthy individuals or those with other conditions.
What were the side effects of ASF?▼
The abstract does not report any adverse effects, but the short 14-day duration and small sample size may not capture all potential side effects.
References
- 1.Das S S, Rm V, Aneesa PA, Joy Parappilly S, Natinga Mulakal J, Chakrapani Ps B, Illathu Madhavamenon K. “Ferula asafoetida oleo-gum resin alleviates dyspepsia symptoms through modulation of microbiome-gut-brain axis: A randomized, double-blind, placebo-controlled study..” Medicine, 2025. PMID: 41054174 DOI: 10.1097/MD.0000000000044590