Ferula asafoetida oleo-gum resin improves sleep quality in individuals with functional dyspepsia symptoms
A 14-day randomized, double-blind, placebo-controlled trial found that 250 mg/day of Ferula asafoetida oleo-gum resin (ASF) significantly improved sleep quality as measured by the Bergen Insomnia Scale (BIS), with a mean change of 10.89 ± 3.23 points (P < .001) compared to placebo. The improvement was observed in 62 participants with functional dyspepsia symptoms.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Ferula asafoetida oleo-gum resin improves sleep quality in individuals with functional dyspepsia symptoms The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 44/100 (low).
The Claim
Ferula asafoetida oleo-gum resin improves sleep quality in individuals with functional dyspepsia symptoms
This conclusion is most relevant to: 62 participants diagnosed with functional dyspepsia symptoms.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Ferula asafoetida oleo-gum resin alleviates dyspepsia symptoms through modulation of microbiome-gut-brain axis: A randomized, double-blind, placebo-controlled study. (Medicine, 2025) —
How It Works
The proposed biological pathway:
- ▸ASF modulates gut microbiota by decreasing Firmicutes-to-Bacteroidetes ratio (71.9%)
- ▸Enhances alpha diversity and enriches beneficial genera (e.g., Bacteroides, Prevotella)
- ▸Reduces harmful taxa (e.g., Escherichia, Clostridia)
- ▸Result: Improved sleep quality via microbiome-gut-brain axis modulation
Who Might Benefit
Evidence fit by population:
- ▸62 participants diagnosed with functional dyspepsia symptoms
Recommended Dose
250 mg/day
Limitations & Caveats
Important context when interpreting this evidence:
- ▸The study duration was only 14 days, limiting assessment of long-term effects
- ▸The sample size was relatively small (n=62), which may reduce generalizability
- ▸Sleep quality was assessed only by a self-report scale (BIS) without objective measures like polysomnography
Frequently Asked Questions
What is the Bergen Insomnia Scale and how was it used?▼
The Bergen Insomnia Scale (BIS) is a validated self-report questionnaire used to assess insomnia symptoms. In this study, it was administered at baseline and day 14 to measure changes in sleep quality.
How does Ferula asafoetida improve sleep?▼
The proposed mechanism is through modulation of the microbiome-gut-brain axis, including reducing the Firmicutes-to-Bacteroidetes ratio and enriching beneficial gut bacteria, which may influence brain function and sleep regulation.
Is this supplement safe for long-term use?▼
The study only tested a 14-day regimen, so long-term safety and efficacy are not established. The authors describe ASF as a food-grade supplement, but further research is needed.
Who might benefit from this supplement?▼
The study focused on individuals with functional dyspepsia symptoms, who also experienced improvements in sleep quality. It may be relevant for those with gut-brain interaction disorders.
References
- 1.Das S S, Rm V, Aneesa PA, Joy Parappilly S, Natinga Mulakal J, Chakrapani Ps B, Illathu Madhavamenon K. “Ferula asafoetida oleo-gum resin alleviates dyspepsia symptoms through modulation of microbiome-gut-brain axis: A randomized, double-blind, placebo-controlled study..” Medicine, 2025. PMID: 41054174 DOI: 10.1097/MD.0000000000044590