Hesperidin synergistically potentiates the sleep-enhancing effect of diazepam in mice.
The study found that hesperidin, a natural flavonoid, synergistically interacts with diazepam to enhance sleep-related behavior as measured in the hole board test. Isobolar analysis confirmed the interaction was synergistic, not additive, and pharmacokinetic effects or direct binding of hesperidin to the benzodiazepine site were ruled out.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Hesperidin synergistically potentiates the sleep-enhancing effect of diazepam in mice. The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
Hesperidin synergistically potentiates the sleep-enhancing effect of diazepam in mice.
This conclusion is most relevant to: Mice (animal study).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Synergistic interaction between hesperidin, a natural flavonoid, and diazepam. (European journal of pharmacology, 2005) —
How It Works
The proposed biological pathway:
- ▸Hesperidin does not bind to the benzodiazepine site on GABA(A) receptors
- ▸Diazepam acts as an agonist at the benzodiazepine binding site
- ▸Co-administration produces synergistic enhancement of sleep effects
- ▸Result: Potentiation of sleep-enhancing properties
Who Might Benefit
Evidence fit by population:
- ▸Mice (animal study)
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Animal study, not directly generalizable to humans
- ▸No specific dose-response data or effect sizes reported in abstract
Frequently Asked Questions
What is hesperidin?▼
Hesperidin is a natural flavonoid found in Valeriana and citrus fruits, with sedative and sleep-enhancing properties.
How does hesperidin interact with diazepam?▼
Hesperidin synergistically potentiates the sleep-enhancing effect of diazepam, meaning the combined effect is greater than the sum of individual effects.
Does hesperidin bind to benzodiazepine receptors?▼
No, hesperidin is not a ligand for the benzodiazepine binding site on GABA(A) receptors.
Could hesperidin reduce the needed dose of benzodiazepines?▼
The authors suggest that hesperidin may allow for lower therapeutic doses of benzodiazepines due to synergistic interaction.
References
- 1.Fernández SP, Wasowski C, Paladini AC, Marder M. “Synergistic interaction between hesperidin, a natural flavonoid, and diazepam..” European journal of pharmacology, 2005. PMID: 15840404 DOI: 10.1016/j.ejphar.2005.02.039