Lactobacillus reuteri E9 regulates sleep disorders through its metabolite GABA by modulating inhibitory neurotransmitters and sleep-related receptor expression.
Lactobacillus reuteri E9 significantly upregulated inhibitory neurotransmitters including GABA, taurine, glycine, and serine (p < 0.05) in a PTZ-induced zebrafish model of sleep disorder. It reduced seizures and hyperactivity, and upregulated GABA receptor genes and melatonin receptor (Mtnr1aa) genes in zebrafish neural tissue.
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Lactobacillus reuteri E9 regulates sleep disorders through its metabolite GABA by modulating inhibitory neurotransmitters and sleep-related receptor expression. The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
Lactobacillus reuteri E9 regulates sleep disorders through its metabolite GABA by modulating inhibitory neurotransmitters and sleep-related receptor expression.
This conclusion is most relevant to: Pentylenetetrazol (PTZ)-induced zebrafish model of sleep disorder.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA. (Frontiers in bioscience (Landmark edition), 2025) —
How It Works
The proposed biological pathway:
- ▸E9 upregulates inhibitory neurotransmitters (GABA, taurine, glycine, serine)
- ▸E9 upregulates GABA receptor gene expression in neural tissue
- ▸E9 upregulates melatonin receptor (Mtnr1aa) gene expression
- ▸Result: Reduced seizures and hyperactivity, sedative effects
Who Might Benefit
Evidence fit by population:
- ▸Pentylenetetrazol (PTZ)-induced zebrafish model of sleep disorder
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Animal model (zebrafish) may not fully translate to human sleep disorders
- ▸Abstract does not report effect sizes or confidence intervals for key outcomes
Frequently Asked Questions
What is Lactobacillus reuteri E9?▼
It is a non-toxic, drug-resistant probiotic strain isolated and characterized for its potential to regulate sleep disorders via the microbiota-gut-brain axis.
How does Lactobacillus reuteri E9 affect sleep?▼
It upregulates inhibitory neurotransmitters like GABA, taurine, glycine, and serine, and increases expression of GABA and melatonin receptor genes, leading to sedative effects in a zebrafish model.
What model was used to test Lactobacillus reuteri E9?▼
A pentylenetetrazol (PTZ)-induced zebrafish model of sleep disorder was used to evaluate its effects.
Is Lactobacillus reuteri E9 safe for humans?▼
The abstract states it is non-toxic and drug-resistant, but human studies are needed to confirm safety and efficacy.
References
- 1.Jiang Y, Guo L, He H, Chen H, Chen T, Liu Y, Zhao W. “Lactobacillus reuteri E9 Regulates Sleep Disorders Through Its Metabolite GABA..” Frontiers in bioscience (Landmark edition), 2025. PMID: 40613302 DOI: 10.31083/FBL39587