Lippia alba non-volatile extract (80% ethanol) shows sedative and myorelaxant effects in mice
The non-volatile fraction of Lippia alba extracted with 80% ethanol (ES(80%)) demonstrated the most significant sedative and myorelaxant effects in Swiss mice, along with the highest total flavonoid content (66 mg/100 g expressed as apigenin). The spray-dried powder SDP(1) (using colloidal silicon dioxide) retained a sedative profile similar to the liquid extract.
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Lippia alba non-volatile extract (80% ethanol) shows sedative and myorelaxant effects in mice The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
Lippia alba non-volatile extract (80% ethanol) shows sedative and myorelaxant effects in mice
This conclusion is most relevant to: Swiss mice.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸CNS activities of liquid and spray-dried extracts from Lippia alba-Verbenaceae (Brazilian false melissa). (Journal of ethnopharmacology, 2003) —
How It Works
The proposed biological pathway:
- ▸Extraction of non-volatile fraction from Lippia alba leaves using ethanol 80%
- ▸Oral administration to mice
- ▸Flavonoid content (66 mg/100 g apigenin) may mediate CNS activity
- ▸Result: Sedative and myorelaxant effects observed
Who Might Benefit
Evidence fit by population:
- ▸Swiss mice
Recommended Dose
200 mg dry residue per kg body weight
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Animal study (mice) with limited generalizability to humans
- ▸No direct measurement of sleep parameters beyond barbiturate-induced sleep test
- ▸Small sample size not explicitly stated in abstract
Frequently Asked Questions
What part of Lippia alba was used in this study?▼
The non-volatile fraction from the leaves was used, extracted with ethanol.
Which extract showed the strongest sedative effect?▼
The liquid extract prepared with 80% ethanol (ES(80%)) showed the most significant sedative and myorelaxant effects.
What was the flavonoid content of the most effective extract?▼
The ES(80%) extract had the highest total flavonoid content at 66 mg per 100 g, expressed as apigenin.
Did the spray-dried powders retain the sedative effect?▼
Only SDP(1), which used colloidal silicon dioxide as excipient, showed a sedative profile similar to the liquid extract ES(80%).
References
- 1.Zétola M, De Lima TC, Sonaglio D, González-Ortega G, Limberger RP, Petrovick PR, Bassani VL. “CNS activities of liquid and spray-dried extracts from Lippia alba-Verbenaceae (Brazilian false melissa)..” Journal of ethnopharmacology, 2003. PMID: 12241997 DOI: 10.1016/s0378-8741(02)00187-3