Lippia alba non-volatile extract (ethanol 80%) has sedative and myorelaxant effects in Swiss mice
The ethanol 80% extract of Lippia alba showed the most significant sedative and myorelaxant effects in Swiss mice, as assessed by the barbiturate-induced sleep test and pentylenetetrazol-induced convulsion test. This extract also had the highest total flavonoid content (66 mg/100 g expressed in apigenin).
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Lippia alba non-volatile extract (ethanol 80%) has sedative and myorelaxant effects in Swiss mice The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
Lippia alba non-volatile extract (ethanol 80%) has sedative and myorelaxant effects in Swiss mice
This conclusion is most relevant to: Swiss mice.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸CNS activities of liquid and spray-dried extracts from Lippia alba-Verbenaceae (Brazilian false melissa). (Journal of ethnopharmacology, 2003) —
How It Works
The proposed biological pathway:
- ▸Extraction of non-volatile fraction from Lippia alba leaves using ethanol 80%
- ▸Oral administration to Swiss mice
- ▸Observation of increased sleep duration and reduced convulsions
- ▸Conclusion: Sedative and myorelaxant effects attributed to flavonoid content
Who Might Benefit
Evidence fit by population:
- ▸Swiss mice
Recommended Dose
200 mg dry residue per kg body weight
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Animal study (mice), not directly generalizable to humans
- ▸Only acute effects tested; no chronic or long-term safety data reported
Frequently Asked Questions
What part of Lippia alba was used in this study?▼
The non-volatile fraction from the leaves was used.
What dose of Lippia alba extract was given to the mice?▼
The dose was 200 mg of dry residue per kilogram of body weight, administered orally.
Which ethanol concentration produced the strongest sedative effect?▼
The ethanol 80% extract showed the most significant sedative and myorelaxant effects.
What was the main active compound measured in the extract?▼
Total flavonoid content was measured, expressed as apigenin, with the highest level (66 mg/100 g) in the ethanol 80% extract.
References
- 1.Zétola M, De Lima TC, Sonaglio D, González-Ortega G, Limberger RP, Petrovick PR, Bassani VL. “CNS activities of liquid and spray-dried extracts from Lippia alba-Verbenaceae (Brazilian false melissa)..” Journal of ethnopharmacology, 2003. PMID: 12241997 DOI: 10.1016/s0378-8741(02)00187-3