Melatonin supplementation may be associated with ventricular arrhythmia in some individuals
A 63-year-old man developed ventricular arrhythmia while taking 10 mg of exogenous melatonin daily, with complete resolution of symptoms and improvement in electrocardiographic findings after discontinuation. A systematic review identified similar arrhythmic events associated with melatonin supplementation, with symptom resolution or clinical improvement after stopping the supplement.
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Melatonin supplementation may be associated with ventricular arrhythmia in some individuals The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 7/100 (low).
The Claim
Melatonin supplementation may be associated with ventricular arrhythmia in some individuals
This conclusion is most relevant to: 63-year-old man (case) and reports from systematic review.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Atrioventricular Block Potentially Associated with Melatonin Supplementation: A Case Report and Systematic Review of Cardiac Rhythm Adverse Events. (Pharmaceuticals (Basel, Switzerland), 2026) —
How It Works
The proposed biological pathway:
- ▸Melatonin receptor activation
- ▸Sleep architecture changes
- ▸Pharmacokinetic variability
- ▸Genetic predisposition
- ▸Cardiac rhythm and conduction disturbances
Who Might Benefit
Evidence fit by population:
- ▸63-year-old man (case) and reports from systematic review
Recommended Dose
10 mg daily
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Single case report with limited generalizability
- ▸Systematic review may include heterogeneous and low-quality reports
Frequently Asked Questions
What dose of melatonin was associated with the arrhythmia?▼
The patient was taking 10 mg of exogenous melatonin daily.
Did the patient recover after stopping melatonin?▼
Yes, the patient experienced complete resolution of symptoms and improvement in electrocardiographic findings after discontinuing melatonin.
Is melatonin generally safe for the heart?▼
Melatonin is generally regarded as safe with cardioprotective effects, but this report and systematic review suggest rare cardiac rhythm adverse events may occur.
What mechanisms might explain melatonin-related arrhythmias?▼
Possible mechanisms include melatonin receptor effects, sleep architecture changes, pharmacokinetic variability, and genetic predisposition.
References
- 1.Sola E, Ramos E, Romero A, Monzón D. “Atrioventricular Block Potentially Associated with Melatonin Supplementation: A Case Report and Systematic Review of Cardiac Rhythm Adverse Events..” Pharmaceuticals (Basel, Switzerland), 2026. PMID: 42515750 DOI: 10.3390/ph19071069