Melatonin treatment during REM sleep deprivation modulates oxidative stress-related parameters by increasing enzymatic antioxidant levels and reducing lipid peroxidation in rats
In a six-day REM sleep deprivation model using the modified multiple platform method, melatonin treatment increased enzymatic antioxidant levels (CAT, SOD, GPx) and reduced lipid peroxidation (MDA) in male Sprague-Dawley rats. Effects on total oxidant status were not significant, and total antioxidant status changes were limited and time-dependent. During recovery, some oxidative stress markers partially normalized, suggesting reactivation of endogenous antioxidant defenses.
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Melatonin treatment during REM sleep deprivation modulates oxidative stress-related parameters by increasing enzymatic antioxidant levels and reducing lipid peroxidation in rats The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
Melatonin treatment during REM sleep deprivation modulates oxidative stress-related parameters by increasing enzymatic antioxidant levels and reducing lipid peroxidation in rats
This conclusion is most relevant to: 8-12-week-old male Sprague-Dawley rats (n=84).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Effect of melatonin treatment on oxidative stress-related parameters in REM sleep-deprived rats. (Molecular and cellular biochemistry, 2026) —
How It Works
The proposed biological pathway:
- ▸REM sleep deprivation increases oxidative stress via ROS accumulation and disrupts oxidant-antioxidant balance
- ▸Melatonin acts as a direct ROS scavenger
- ▸Melatonin supports endogenous antioxidant defense mechanisms
- ▸Melatonin increases enzymatic antioxidant levels and reduces lipid peroxidation
- ▸Result: Attenuation of some oxidative stress alterations, with effects varying by timing and parameter
Who Might Benefit
Evidence fit by population:
- ▸8-12-week-old male Sprague-Dawley rats (n=84)
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Animal study (rats), not directly generalizable to humans
- ▸Specific dose and administration route of melatonin not reported in abstract
- ▸Only six-day REM-SD period; long-term effects not assessed
- ▸No significant change in TOS, and TAS effect limited and time-dependent
Frequently Asked Questions
Does melatonin reduce oxidative stress caused by REM sleep deprivation?▼
Yes, in this rat study, melatonin treatment increased enzymatic antioxidant levels and reduced lipid peroxidation, but did not significantly affect total oxidant status.
What oxidative stress markers were measured in this study?▼
Total antioxidant status (TAS), total oxidant status (TOS), malondialdehyde (MDA), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx).
How was REM sleep deprivation induced in the rats?▼
Using the modified multiple platform method (MMPM) over a six-day period.
Did melatonin have any effect on total oxidant status?▼
No significant change was observed in total oxidant status (TOS).
References
- 1.Sehzade S, Cakir A, Koc C, Kahveci N. “Effect of melatonin treatment on oxidative stress-related parameters in REM sleep-deprived rats..” Molecular and cellular biochemistry, 2026. PMID: 42566144 DOI: 10.1007/s11010-026-05686-9