PRF plus PRP improves pain, sleep quality, quality of life, and inflammation more than PRF alone or PRF plus ozone in postherpetic neuralgia patients at 90 days
In a single-center RCT of 122 adults aged 50-70 with single-segment PHN lasting >3 months, PRF plus PRP showed significantly greater improvement at 90 days compared to PRF alone and PRF plus ozone. VAS reduction was -2.49 (95% CI, -2.88 to -2.10) vs PRF alone and -1.43 (-1.80 to -1.05) vs PRF plus ozone; PSQI improved by -5.72 (-7.09 to -4.36) and -4.77 (-6.09 to -3.44), respectively; all adjusted P values <0.001.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
PRF plus PRP improves pain, sleep quality, quality of life, and inflammation more than PRF alone or PRF plus ozone in postherpetic neuralgia patients at 90 days The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 44/100 (low).
The Claim
PRF plus PRP improves pain, sleep quality, quality of life, and inflammation more than PRF alone or PRF plus ozone in postherpetic neuralgia patients at 90 days
This conclusion is most relevant to: Adults aged 50-70 years with single-segment postherpetic neuralgia lasting >3 months.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸CT-Guided Dorsal Root Ganglion Pulsed Radiofrequency Alone, with Ozone, or with Platelet-Rich Plasma for Postherpetic Neuralgia: A Randomized Controlled Trial. (Journal of pain research, 2026) —
How It Works
The proposed biological pathway:
- ▸PRF modulates dorsal root ganglion activity
- ▸PRP provides growth factors and anti-inflammatory cytokines
- ▸Combined effect reduces neuropathic pain and inflammation
- ▸Result: greater multidimensional improvement in pain, sleep, quality of life, and NLR
Who Might Benefit
Evidence fit by population:
- ▸Adults aged 50-70 years with single-segment postherpetic neuralgia lasting >3 months
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Single-center design limits generalizability
- ▸Results require validation in larger, well-designed multicenter randomized trials
- ▸Complete-case/per-protocol analysis may introduce bias if dropouts were not random
Frequently Asked Questions
What is the main finding of this study?▼
PRF plus PRP was more effective than PRF alone or PRF plus ozone for improving pain, sleep quality, quality of life, and inflammation in postherpetic neuralgia patients at 90 days.
How many participants were in the study?▼
122 participants completed the trial: 38 in PRF alone, 43 in PRF plus ozone, and 41 in PRF plus PRP.
What outcomes were measured?▼
Pain (VAS), sleep quality (PSQI), quality of life (SF-12), and inflammation (neutrophil-to-lymphocyte ratio) were assessed at baseline and 30, 60, and 90 days.
Are there any safety concerns with PRP?▼
No PRP-related complications were observed in this study.
References
- 1.Cao K, Wu J, Zhang J. “CT-Guided Dorsal Root Ganglion Pulsed Radiofrequency Alone, with Ozone, or with Platelet-Rich Plasma for Postherpetic Neuralgia: A Randomized Controlled Trial..” Journal of pain research, 2026. PMID: 42502491 DOI: 10.2147/JPR.S605629