Probiotic supplementation (Cerebiome) improves depressive symptoms but not insomnia symptoms in adults with mild-to-moderate insomnia and work-related stress
In a 12-week randomized, placebo-controlled, double-blind trial, adults with mild-to-moderate insomnia and work-related stress received either Cerebiome probiotic or placebo. Both groups showed significant reductions in insomnia severity, but there was no significant between-group difference. The probiotic group showed a significant improvement in depressive symptoms (PHQ-9) compared to placebo.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Probiotic supplementation (Cerebiome) improves depressive symptoms but not insomnia symptoms in adults with mild-to-moderate insomnia and work-related stress The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 53/100 (low).
The Claim
Probiotic supplementation (Cerebiome) improves depressive symptoms but not insomnia symptoms in adults with mild-to-moderate insomnia and work-related stress
This conclusion is most relevant to: Adults aged 18-65 with mild-to-moderate insomnia symptoms and work-related stress, without mental disorder or severe psychosocial distress.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Effects of probiotic supplementation on sleep and psychological outcomes in adults with mild-to-moderate insomnia symptoms and work-related stress: A randomized, placebo-controlled, double-blind trial. (Sleep medicine, 2026) —
How It Works
The proposed biological pathway:
- ▸Probiotic supplementation modulates gut microbiota
- ▸Gut-brain axis influences mood regulation
- ▸Improved depressive symptoms observed
- ▸No effect on insomnia symptoms
Who Might Benefit
Evidence fit by population:
- ▸Adults aged 18-65 with mild-to-moderate insomnia symptoms and work-related stress, without mental disorder or severe psychosocial distress
Recommended Dose
Not specified (Cerebiome probiotic supplement, daily)
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Small sample size (n=70)
- ▸No significant effect on primary outcome (insomnia severity)
- ▸Potential placebo effect in both groups
- ▸Short duration (12 weeks)
Frequently Asked Questions
Does Cerebiome probiotic improve insomnia?▼
No, the study found no significant difference between probiotic and placebo groups in reducing insomnia severity.
What is Cerebiome probiotic?▼
Cerebiome is a probiotic supplement tested in this trial for its effects on sleep and mood.
Who was eligible for this study?▼
Adults aged 18-65 with mild-to-moderate insomnia symptoms and work-related stress, without mental disorders or severe psychosocial distress.
What were the main outcomes?▼
The primary outcome was change in Insomnia Severity Index score; secondary outcomes included depressive symptoms, sleep quality, and quality of life.
References
- 1.Binda S, Auclair-Ouellet N, Kassem O, Ivers H, Milev R, Lamy M, Chen S, Oula ML, Morin CM. “Effects of probiotic supplementation on sleep and psychological outcomes in adults with mild-to-moderate insomnia symptoms and work-related stress: A randomized, placebo-controlled, double-blind trial..” Sleep medicine, 2026. PMID: 42628338 DOI: 10.1016/j.sleep.2026.109223