Resveratrol, epigallocatechin gallate, curcumin, jaceosidin, cucurbitacin, apigenin, and genistein trigger activation of ATM in different cancer cells, while some agents cause ATM inactivation.
This review summarizes evidence from cell-based studies that various phytochemicals modulate ATM, the master regulator of DNA double-strand break repair. Specific compounds like resveratrol and curcumin activate ATM in cancer cells, while other agents can inactivate it, suggesting potential therapeutic applications for enhancing DNA damage-inducing therapy.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Resveratrol, epigallocatechin gallate, curcumin, jaceosidin, cucurbitacin, apigenin, and genistein trigger activation of ATM in different cancer cells, while some agents cause ATM inactivation. The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 32/100 (low).
The Claim
Resveratrol, epigallocatechin gallate, curcumin, jaceosidin, cucurbitacin, apigenin, and genistein trigger activation of ATM in different cancer cells, while some agents cause ATM inactivation.
This conclusion is most relevant to: Different cancer cell lines (in vitro cell-based studies).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Activation and Inhibition of ATM by Phytochemicals: Awakening and Sleeping the Guardian Angel Naturally. (Archivum immunologiae et therapiae experimentalis, 2016) —
How It Works
The proposed biological pathway:
- ▸Phytochemicals interact with ATM signaling pathways
- ▸ATM activation triggers DNA damage response checkpoints
- ▸ATM modulates TRAIL-induced intracellular signaling network
- ▸Result: Enhanced or suppressed DNA repair and apoptosis in cancer cells
Who Might Benefit
Evidence fit by population:
- ▸Different cancer cell lines (in vitro cell-based studies)
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Evidence is based solely on cell-based studies, not in vivo or clinical trials
- ▸The review does not provide specific quantitative data on efficacy or potency of individual phytochemicals
Frequently Asked Questions
Which phytochemicals activate ATM in cancer cells?▼
Resveratrol, epigallocatechin gallate, curcumin, jaceosidin, cucurbitacin, apigenin, and genistein are reported to trigger ATM activation in different cancer cell lines.
What is the role of ATM in cancer therapy?▼
ATM is the master regulator of DNA double-strand break repair. Modulating ATM activity with phytochemicals may enhance the response to DNA damage-inducing therapies like radiation or chemotherapy.
Are these findings from human studies?▼
No, the evidence comes from cell-based (in vitro) studies, not human clinical trials.
Can phytochemicals also inactivate ATM?▼
Yes, the review mentions that some agents can cause ATM inactivation, though specific compounds are not detailed in the abstract.
References
- 1.Farooqi AA, Wu SJ, Chang YT, Tang JY, Li KT, Ismail M, Liaw CC, Li RN, Chang HW. “Activation and Inhibition of ATM by Phytochemicals: Awakening and Sleeping the Guardian Angel Naturally..” Archivum immunologiae et therapiae experimentalis, 2016. PMID: 26089209 DOI: 10.1007/s00005-015-0346-x