Sleep difficulties are associated with lower health-related quality of life in adults with pulmonary hypertension, partially mediated by depressive symptoms.
In a cross-sectional survey of 111 adults with pulmonary hypertension, 79.8% had poor sleep quality, and insomnia and daytime sleepiness were elevated (35% and 33.6%, respectively). All types of sleep difficulties were associated with lower HRQoL, and this association was partially mediated by depressive symptoms.
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Sleep difficulties are associated with lower health-related quality of life in adults with pulmonary hypertension, partially mediated by depressive symptoms. The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 32/100 (low).
The Claim
Sleep difficulties are associated with lower health-related quality of life in adults with pulmonary hypertension, partially mediated by depressive symptoms.
This conclusion is most relevant to: Adults with pulmonary hypertension (PH) recruited from PH associations globally (91% White, 82% female).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸How Do Sleep Difficulties Interact With Anxiety, Depression and Health-Related Quality of Life in Pulmonary Hypertension? (The clinical respiratory journal, 2026) —
How It Works
The proposed biological pathway:
- ▸Sleep difficulties are prevalent in PH patients
- ▸Sleep difficulties are associated with lower HRQoL
- ▸Depressive symptoms partially mediate the association between sleep difficulties and HRQoL
- ▸Result: Sleep difficulties impact HRQoL partly through depression
Who Might Benefit
Evidence fit by population:
- ▸Adults with pulmonary hypertension (PH) recruited from PH associations globally (91% White, 82% female)
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Cross-sectional design prevents causal inference
- ▸Sample is predominantly White and female, limiting generalizability
- ▸Self-reported measures may be subject to recall bias
Frequently Asked Questions
What percentage of pulmonary hypertension patients have poor sleep quality?▼
79.8% of the 111 participants had poor sleep quality as measured by the Pittsburgh Sleep Quality Index.
Are sleep difficulties linked to depression in pulmonary hypertension?▼
Yes, depressive symptoms partially mediated the association between sleep difficulties and lower health-related quality of life.
What types of sleep difficulties were most common in this study?▼
Sleep disturbance and sleep latency issues were the most prevalent sleep-related difficulties.
What is the recommended clinical action based on this study?▼
The findings indicate the need to routinely screen for both sleep difficulties and mood disturbance in pulmonary hypertension patients.
References
- 1.Green JL, Costin V, Armstrong I, Thompson AR, Rawlings GH. “How Do Sleep Difficulties Interact With Anxiety, Depression and Health-Related Quality of Life in Pulmonary Hypertension?.” The clinical respiratory journal, 2026. PMID: 42538807 DOI: 10.1111/crj.70220