Standardized lime peel supplement (SLPS) reduces sleep latency and improves sleep efficiency in adults with sleep disturbance
In a randomized, double-blind, placebo-controlled trial, 80 adults with sleep disturbances received 300 mg/day of SLPS or placebo for 2 weeks. SLPS significantly improved polysomnographic outcomes, including reduced sleep latency, wake after sleep onset, and total wake time, as well as enhanced sleep efficiency, total sleep time, and stage 2 sleep. Daytime sleepiness was also decreased, with no serious adverse effects reported.
This article is automatically generated from the structured evidence profile behind the claim above. Scores reflect the quality and quantity of available research, not clinical advice.
Standardized lime peel supplement (SLPS) reduces sleep latency and improves sleep efficiency in adults with sleep disturbance The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 42/100 (low).
The Claim
Standardized lime peel supplement (SLPS) reduces sleep latency and improves sleep efficiency in adults with sleep disturbance
This conclusion is most relevant to: Adults with sleep disturbances (80 subjects).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study. (Phytomedicine : international journal of phytotherapy and phytopharmacology, 2025) —
How It Works
The proposed biological pathway:
- ▸SLPS activates GABAA receptors (based on prior mouse study)
- ▸Induces non-rapid eye movement sleep
- ▸Shortens sleep latency
- ▸Result: Improved sleep quality and reduced daytime sleepiness
Who Might Benefit
Evidence fit by population:
- ▸Adults with sleep disturbances (80 subjects)
Recommended Dose
300 mg/day
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Short 2-week intervention period limits assessment of long-term efficacy and safety
- ▸Mechanism of action is inferred from animal studies, not directly measured in humans
Frequently Asked Questions
What is standardized lime peel supplement (SLPS)?▼
SLPS is a supplement derived from citrus peels, rich in flavonoids, that has shown sedative-hypnotic effects in animal studies and is being tested for sleep improvement in humans.
How was sleep measured in this study?▼
Sleep was measured using polysomnography, an objective method that records brain waves, eye movements, and other physiological signals during sleep, along with the Epworth Sleepiness Scale for daytime sleepiness.
Were there any side effects of SLPS?▼
No serious adverse effects or side effects were reported among participants in the SLPS group during the 2-week intervention period.
Is SLPS effective for all types of sleep disturbances?▼
This study focused on adults with general sleep disturbances; the results suggest benefits for sleep latency and efficiency, but further research is needed for specific conditions like insomnia.
References
- 1.Kim S, Um MY, Han JK, Kim D, Choi Y, Choi G, Bang C, Oh Y, Youn JH, Cho S. “Efficacy and safety of standardized lime peel supplement in adults with sleep disturbance: A randomized, double-blind, placebo-controlled, polysomnographic study..” Phytomedicine : international journal of phytotherapy and phytopharmacology, 2025. PMID: 39970858 DOI: 10.1016/j.phymed.2025.156510