Taxifolin modulates circadian protein expression in a manner comparable to melatonin
Taxifolin, identified via virtual screening against the melatonin 1 receptor (MT1), showed a binding affinity of -9.527 kcal/mol and formed stable protein-ligand complexes in molecular dynamics simulations. Immunocytochemistry analysis indicated that taxifolin modulated circadian regulators CLOCK and BMAL1 expression similarly to melatonin in cellular models.
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Taxifolin modulates circadian protein expression in a manner comparable to melatonin The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
Taxifolin modulates circadian protein expression in a manner comparable to melatonin
This conclusion is most relevant to: In silico models and cellular models (immunocytochemistry analysis).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Integrative network pharmacology and molecular modelling identify taxifolin as a potential modulator of melatonin receptor MT1 in mood disorders. (Molecular diversity, 2026) —
How It Works
The proposed biological pathway:
- ▸Taxifolin binds to melatonin receptor MT1 with high affinity (-9.527 kcal/mol)
- ▸Forms stable protein-ligand complex with sustained hydrogen bonding and reduced RMSD/RMSF fluctuations
- ▸Modulates circadian protein expression (CLOCK and BMAL1) in a manner comparable to melatonin
- ▸Indicates potential stabilization of melatonergic signaling in circadian-mood pathways
Who Might Benefit
Evidence fit by population:
- ▸In silico models and cellular models (immunocytochemistry analysis)
Recommended Dose
N/A
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Preliminary biological validation only via immunocytochemistry; no in vivo or clinical data provided
- ▸Computational modeling results require experimental confirmation of functional effects on mood disorders
Frequently Asked Questions
What is taxifolin?▼
Taxifolin is a natural flavonoid compound identified in this study as a potential modulator of the melatonin receptor MT1, showing high binding affinity and stable complex formation.
How was taxifolin identified?▼
Taxifolin was identified through structure-based virtual screening of approximately 150,000 natural compounds against the melatonin 1 receptor (MT1), followed by molecular dynamics simulations.
What does taxifolin do to circadian proteins?▼
Taxifolin modulated the expression of circadian regulators CLOCK and BMAL1 in a manner comparable to melatonin, as shown by immunocytochemistry analysis.
Is taxifolin a replacement for melatonin?▼
The study suggests taxifolin may be a safer natural alternative to synthetic melatonergic agents, but further research is needed to confirm its efficacy in mood disorders.
References
- 1.Bartwal SS, Chhabra V, Rai A, Murti K, Kumar N. “Integrative network pharmacology and molecular modelling identify taxifolin as a potential modulator of melatonin receptor MT1 in mood disorders..” Molecular diversity, 2026. PMID: 42377825 DOI: 10.1007/s11030-026-11630-2