TruCBN™ has no adverse effects in rats at doses up to 400 mg/kg/day in oral toxicity studies
In 14-day and 90-day repeat-dose oral toxicity studies in Sprague-Dawley rats, TruCBN™ showed no adverse effects at doses of 100, 200, and 400 mg/kg/day. The no-observed-adverse-effect-level (NOAEL) was established at 400 mg/kg/day.
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TruCBN™ has no adverse effects in rats at doses up to 400 mg/kg/day in oral toxicity studies The current body of evidence comprises 1 study. EvidenceHub rates the overall confidence at 24/100 (low).
The Claim
TruCBN™ has no adverse effects in rats at doses up to 400 mg/kg/day in oral toxicity studies
This conclusion is most relevant to: Male and female Sprague-Dawley rats.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Investigation into the oral toxicity profile of TruCBN™. (Toxicology reports, 2026) —
How It Works
The proposed biological pathway:
- ▸CBN acts as a low affinity partial agonist at CB1 and CB2 receptors
- ▸Greater affinity for CB2 receptors
- ▸No observed toxicological effects at tested doses
- ▸Result: NOAEL of 400 mg/kg/day in rats
Who Might Benefit
Evidence fit by population:
- ▸Male and female Sprague-Dawley rats
Recommended Dose
400 mg/kg/day (NOAEL)
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Animal study; results may not directly translate to humans
- ▸Only tested up to 400 mg/kg/day; higher doses might show adverse effects
- ▸No sleep-specific outcomes measured despite mention of sleep quality relevance
Frequently Asked Questions
What is TruCBN™?▼
TruCBN™ is a proprietary high-purity cannabinol (CBN) isolate processed to be substantially free of THC, derived from Cannabis sativa.
What was the highest safe dose of TruCBN™ in this study?▼
The no-observed-adverse-effect-level (NOAEL) was 400 mg/kg/day in rats, the highest dose tested.
Does this study prove TruCBN™ is safe for humans?▼
No, this is an animal study. Human safety requires clinical trials, though these results support further investigation.
What are the potential therapeutic uses of CBN mentioned?▼
Potential uses include ocular disease, neuroprotection, antimicrobial, anti-inflammatory, immunosuppressive effects, and sleep quality improvement.
References
- 1.Bauter MR, Hartung V, Dunn C, Jensen RP, McCormick M, Roberts M, DiCarlo-Emery D. “Investigation into the oral toxicity profile of TruCBN™..” Toxicology reports, 2026. PMID: 42383225 DOI: 10.1016/j.toxrep.2026.102296