Withania somnifera and Rhodiola rosea improve sleep quality in healthy individuals and patients with stress-related disorders
A systematic review of 24 RCTs (19 on W. somnifera, 5 on R. rosea) found that supplementation with standardized extracts improved sleep quality. Doses ranged from 120-1000 mg/day for W. somnifera and 290-1500 mg/day for R. rosea, with treatment lasting 3-16 weeks.
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Withania somnifera and Rhodiola rosea improve sleep quality in healthy individuals and patients with stress-related disorders The current body of evidence comprises 1 study, including 1 randomized controlled trial. EvidenceHub rates the overall confidence at 42/100 (low).
The Claim
Withania somnifera and Rhodiola rosea improve sleep quality in healthy individuals and patients with stress-related disorders
This conclusion is most relevant to: Healthy individuals and patients with stress-related or functional disorders, aged 18-75 years, sample sizes 10-590.
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes. (Annals of agricultural and environmental medicine : AAEM, 2026) —
How It Works
The proposed biological pathway:
- ▸Regulation of hypothalamic-pituitary-adrenal (HPA) axis
- ▸Modulation of neurotransmission pathways
- ▸Influence on immune and hormonal pathways
- ▸Result: Improved stress resilience and sleep quality
Who Might Benefit
Evidence fit by population:
- ▸Healthy individuals and patients with stress-related or functional disorders, aged 18-75 years, sample sizes 10-590
Recommended Dose
120-1000 mg/day for W. somnifera; 290-1500 mg/day for R. rosea
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Methodological heterogeneity across studies
- ▸Short intervention periods (3-16 weeks)
- ▸Small sample sizes in many trials
Frequently Asked Questions
What doses of ashwagandha were used in the reviewed studies?▼
Daily doses of standardized Withania somnifera extract ranged from 120 to 1000 mg.
How long did participants take the supplements in these trials?▼
Supplementation lasted between 3 and 16 weeks.
Were the participants healthy or did they have medical conditions?▼
Both healthy individuals and patients with stress-related or functional disorders were included.
What is the main mechanism by which these adaptogens improve sleep?▼
They regulate the hypothalamic-pituitary-adrenal axis, neurotransmission, and immune/hormonal pathways.
References
- 1.Łuszczak J, Kocki J. “Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes..” Annals of agricultural and environmental medicine : AAEM, 2026. PMID: 41906501 DOI: 10.26444/aaem/213417