Withania somnifera improves anxiety symptoms in individuals with mental disorders
This systematic review and meta-analysis of 14 RCTs found that Withania somnifera significantly reduced anxiety symptoms compared to controls, with an outlier-corrected standardized mean difference of -1.13 (95% CI: -1.65 to -0.60). The effect was confirmed using Bayesian analysis for anxiety, but not for depression. The median dose was 600 mg/day over 8 weeks.
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Withania somnifera improves anxiety symptoms in individuals with mental disorders The current body of evidence comprises 1 study and 1 meta-analysis. EvidenceHub rates the overall confidence at 49/100 (low).
The Claim
Withania somnifera improves anxiety symptoms in individuals with mental disorders
This conclusion is most relevant to: Individuals with mental disorders (predominantly anxiety disorders), total 713 participants (360 treated, 353 controls).
What the Research Shows
The conclusion draws on 1 linked study. Highlights from the cited literature:
- ▸The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals with mental disorders: systematic review and meta-analysis. (BJPsych open, 2025) —
How It Works
The proposed biological pathway:
- ▸Withania somnifera acts as an adaptogen
- ▸Reported antistress and anti-inflammatory properties
- ▸May modulate cortisol and neurotransmitter systems
- ▸Result: Reduction in anxiety symptoms
Who Might Benefit
Evidence fit by population:
- ▸Individuals with mental disorders (predominantly anxiety disorders), total 713 participants (360 treated, 353 controls)
Recommended Dose
600 mg/day (median)
Limitations & Caveats
Important context when interpreting this evidence:
- ▸Small number of included studies (14) and substantial between-study heterogeneity
- ▸Outlier effects required correction, and Bayesian analysis confirmed anxiety effect but not depression effect
Frequently Asked Questions
What is the recommended dose of Ashwagandha for anxiety?▼
The median dose used in the reviewed studies was 600 mg/day, administered orally for a median of 8 weeks.
Is Ashwagandha effective for depression?▼
The meta-analysis showed a significant effect on depression symptoms (SMD: -1.28), but this was not confirmed by Bayesian analysis, so evidence is less robust than for anxiety.
How safe is Ashwagandha for mental health conditions?▼
No significant difference in safety and tolerability was found between Ashwagandha and comparators, suggesting it is generally well-tolerated.
Does Ashwagandha improve sleep quality?▼
Yes, the study found a significant improvement in sleep quality (SMD: -1.35, 95% CI: -1.79 to -0.91), though the authors note further research is needed.
References
- 1.Marchi M, Grenzi P, Travascio A, Uberti D, De Micheli E, Quartaroli F, Laquatra G, Pingani L, Ferrari S, Galeazzi GM. “The effect of Withania somnifera (Ashwagandha) on mental health symptoms in individuals with mental disorders: systematic review and meta-analysis..” BJPsych open, 2025. PMID: 41140145 DOI: 10.1192/bjo.2025.10885