Supplements

Anshen Buxin Liuwei Pill improves cardiac neurosis symptoms, anxiety, depression, and sleep quality in patients with heyisheng-type palpitation

In a randomized, double-blind, placebo-controlled trial, Anshen Buxin Liuwei Pill significantly improved cardiac neurosis symptoms (effective rate 83.00% vs 34.80% at week 8) and showed longer-term benefits in anxiety, depression, and sleep quality. The drug was safe and well-tolerated.

Last updated: Aug 14, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score44/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Anshen Buxin Liuwei Pill for the treatment of cardiac neurosis (heyisheng-type palpitation): a randomized, double-blind clinical trial.

observational

Lan Y, Zheng C, Liu J, Nashun D, Ma J, Li G, Yin G, Ma L · Journal of thoracic disease (2026)

Participants: N/A
Duration: 8 weeks
Intervention: Anshen Buxin Liuwei Pill (oral, 8 weeks)
Outcome: Cardiac Neurosis Self-Rating Scale, anxiety, depression, sleep quality, hs-CRP, 5-HT
Effect Size: Between-group difference in effective rate: 48.20% (95% CI: 36.05-60.35%)
Population: Patients with cardiac neurosis (heyisheng-type palpitation), n=182

Result:

PubMed: 42583339DOI: 10.21037/jtd-2026-1612

Mechanism Graph

Anshen Buxin Liuwei Pill acts on cardiac neurosis symptoms
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It alleviates anxiety and depression
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It improves sleep quality
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Result: Significant clinical improvement in symptoms and mood/sleep scores

Limitations

  • ⚠No significant differences in hs-CRP and 5-HT between groups, suggesting unclear biological mechanism
  • ⚠High dropout rate (9 per group) may affect results
  • ⚠Single-center trial with specific population (Mongolian medicine context) may limit generalizability

Frequently Asked Questions

What is the effective rate of Anshen Buxin Liuwei Pill for cardiac neurosis?▼

At week 8, the effective rate was 83.00% (95% CI: 75.32-90.68%) in the treatment group versus 34.80% (95% CI: 25.07-44.53%) in the placebo group.

Does Anshen Buxin Liuwei Pill improve sleep quality?▼

Yes, the trial reported longer-term benefits in sleep quality, with significantly better sleep scores at weeks 2, 8, and 12 compared to placebo.

What is the study design and sample size?▼

It is a randomized, double-blind, placebo-controlled trial with 182 participants (91 per group) who received 8 weeks of treatment and were followed up to week 12.

Are there any side effects?▼

The study reported a favorable safety profile, with no significant adverse events attributed to the drug; one dropout in the control group was related to hypertension adverse event.

Products

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References

  1. 1.Lan Y, Zheng C, Liu J, Nashun D, Ma J, Li G, Yin G, Ma L. "Anshen Buxin Liuwei Pill for the treatment of cardiac neurosis (heyisheng-type palpitation): a randomized, double-blind clinical trial.." Journal of thoracic disease, 2026. PMID: 42583339 DOI: 10.21037/jtd-2026-1612
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.