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Ayurvedic nutritional supplements and yoga protocol reduce the incidence and severity of acute mountain sickness in healthy personnel at high altitudes

This RCT protocol aims to assess the effectiveness of Ayurvedic nutritional supplements (Ayur-nutri kit and cardiac care tea) combined with a daily yoga protocol in reducing AMS incidence and severity among 1660 healthy personnel stationed at high altitudes (9,000–15,000 feet) in the western Himalayas. The primary outcome is AMS incidence measured by Lake Louise Scoring System ≥6 during the first 7 days. Data collection is complete, but analysis is ongoing; results are expected by December 2026.

Last updated: Aug 26, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score44/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Effectiveness of Ayurvedic Nutritional Supplements and Yoga Protocol in Reducing the Incidence and Severity of Acute Mountain Sickness (AYAMS Study): Study Protocol for an Open-Label Randomized Controlled Trial.

observational

Rai AK, Jameela S, Yadav AK, Joshi RK, Mundada P, Ahmad A, Mahajon B, Sharma BS, Khanduri S, Yadav B, Tripathi A, Rana RK, Chandrasekhararao B, Srikanth N, Rao R, Acharya R · JMIR research protocols (2026)

Participants: N/A
Duration: 120 days
Intervention: Ayurvedic nutritional supplements (Ayur-nutri kit 25g and Ayush cardiac care tea 125 mL twice daily) plus yoga protocol (60 min daily) for 120 days, in addition to standard acclimatization schedule
Outcome: Incidence of AMS (Lake Louise Scoring System score ≥6 during first 7 days); secondary outcomes include thromboembolic events, coagulation markers, inflammatory markers, negative emotional states (DASS-21), sleep quality (PSQI), and quality of life (SF-12)
Effect Size: N/A (results not yet published)
Population: Apparently healthy individuals of any gender aged 18–50 years stationed at high altitudes (9,000–15,000 feet) in the western Himalayas

Result:

PubMed: 41950501DOI: 10.2196/81567

Mechanism Graph

Ayurvedic supplements may improve physiological adaptation to hypoxia
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Yoga protocol may enhance respiratory function and reduce stress
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Combined intervention may modulate coagulation, hemostasis, and inflammatory markers
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Result: Reduced incidence and severity of AMS

Limitations

  • ⚠Open-label design may introduce bias due to lack of blinding
  • ⚠Results are not yet available; only the protocol is described
  • ⚠Study conducted in a specific geographic region (western Himalayas), limiting generalizability

Frequently Asked Questions

What is the Lake Louise Scoring System threshold used in this study?▼

The primary outcome is AMS defined as a Lake Louise Scoring System score of 6 or higher during the first 7 days from baseline.

How many participants were enrolled in the AYAMS study?▼

A total of 1660 participants were enrolled, with 830 per altitude stage (stage I: 9,000–12,000 ft; stage II: 12,000–15,000 ft).

When are the results of this trial expected to be published?▼

The study outcomes are expected to be published by December 2026.

What are the secondary outcomes measured in this trial?▼

Secondary outcomes include thromboembolic events, changes in coagulation and inflammatory markers, and changes in depression, anxiety, stress (DASS-21), sleep quality (PSQI), and quality of life (SF-12) at day 60 and day 120.

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References

  1. 1.Rai AK, Jameela S, Yadav AK, Joshi RK, Mundada P, Ahmad A, Mahajon B, Sharma BS, Khanduri S, Yadav B, Tripathi A, Rana RK, Chandrasekhararao B, Srikanth N, Rao R, Acharya R. "Effectiveness of Ayurvedic Nutritional Supplements and Yoga Protocol in Reducing the Incidence and Severity of Acute Mountain Sickness (AYAMS Study): Study Protocol for an Open-Label Randomized Controlled Trial.." JMIR research protocols, 2026. PMID: 41950501 DOI: 10.2196/81567
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.