B-group vitamins (B6, B12, folate) are cofactors in serotonin and GABA synthesis; their deficiency increases neuronal excitability and interferes with sleep.
The review states that B-group vitamins (B6, B12, folate) act as cofactors in the synthesis of serotonin and GABA. A lack of these vitamins increases neuronal excitability and disrupts sleep. No specific effect sizes or numerical data are provided.
Evidence Score
Study Evidence
Study 1. Nutritional modulators of sleep: A narrative review of vitamins, minerals, amino acids, and their neurobiological and chronoepigenetic mechanisms.
observationalKhosropanah A, Hosseini SA, Keshavarz A · Chronobiology international (2026)
Result:
Mechanism Graph
Limitations
- ⚠Narrative review design, not a systematic review or meta-analysis
- ⚠No specific effect sizes or quantitative data reported for this claim
Frequently Asked Questions
Which B vitamins are involved in sleep regulation?▼
Vitamin B6, B12, and folate are identified as cofactors in serotonin and GABA synthesis, which are important for sleep.
How do B-group vitamin deficiencies affect sleep?▼
Deficiencies increase neuronal excitability and interfere with sleep, likely due to reduced serotonin and GABA production.
Is there a recommended dose of B vitamins for sleep?▼
No specific dose is recommended in this review; it only discusses the role of these vitamins as cofactors.
What is the mechanism linking B vitamins to sleep?▼
B vitamins are cofactors for enzymes that synthesize serotonin and GABA, neurotransmitters that promote sleep and reduce neuronal excitability.
Products
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References
- 1.Khosropanah A, Hosseini SA, Keshavarz A. "Nutritional modulators of sleep: A narrative review of vitamins, minerals, amino acids, and their neurobiological and chronoepigenetic mechanisms.." Chronobiology international, 2026. PMID: 41992896 DOI: 10.1080/07420528.2026.2648011