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Balance and sleep quality are significantly associated with attentional processing in Parkinson's disease, as measured by P300 latency

In a cross-sectional study of 28 individuals with Parkinson's disease and 27 healthy controls, balance (B = -4.909, P = 0.001) and sleep quality (B = 12.704, P = 0.007) were significantly associated with P300 latency, indicating their relevance to attention. Depression was not significantly associated with P300 latency (B = 3.472, P = 0.084).

Last updated: Jul 31, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Assessment of balance, sleep quality, and depression in relation to attention in Parkinson's disease: A cross-sectional P300 study.

observational

Ozaltin GE, Simsek A, Candiri B, Algul FE, Tecellioglu M, Talu B · Sao Paulo medical journal = Revista paulista de medicina (2026)

Participants: N/A
Duration: N/A
Intervention: Observational assessment of balance, sleep quality, and depression
Outcome: Attention measured by auditory event-related potential P300 latency
Effect Size: N/A
Population: 28 individuals with Parkinson's disease and 27 healthy controls

Result:

PubMed: 42484116DOI: 10.1590/1516-3180.2026.3465.10032026

Mechanism Graph

Parkinson's disease involves neurodegeneration affecting motor and non-motor functions
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Balance deficits and poor sleep quality may impair cognitive processing resources
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P300 latency reflects attention and discrimination processes
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Result: Balance and sleep quality are significantly associated with attentional processing in PD

Limitations

  • ⚠Cross-sectional design prevents causal inference
  • ⚠Small sample size (28 PD patients) limits generalizability

Frequently Asked Questions

What is P300 latency and why is it used to measure attention?▼

P300 latency is an auditory event-related potential that reflects the speed of neural processing related to attention and discrimination. It is a sensitive indicator of attentional deficits in neurological conditions like Parkinson's disease.

How was balance assessed in this study?▼

Balance was assessed using the Berg Balance Scale (BBS), a clinical test that evaluates functional balance through tasks like standing, reaching, and turning.

Did depression significantly affect attention in Parkinson's disease patients?▼

No, depression as measured by the Beck Depression Inventory was not significantly associated with P300 latency (B = 3.472, P = 0.084), suggesting it may not independently impact attentional processing in this sample.

What are the clinical implications of this study?▼

The findings suggest that balance training and improving sleep quality may be relevant targets for managing attention deficits in Parkinson's disease, though further research is needed.

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References

  1. 1.Ozaltin GE, Simsek A, Candiri B, Algul FE, Tecellioglu M, Talu B. "Assessment of balance, sleep quality, and depression in relation to attention in Parkinson's disease: A cross-sectional P300 study.." Sao Paulo medical journal = Revista paulista de medicina, 2026. PMID: 42484116 DOI: 10.1590/1516-3180.2026.3465.10032026
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.