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Caffeine use disorder has a direct effect on sleep problems and an indirect effect through depressive symptoms among university students

In a cross-sectional study of 530 Bangladeshi university students, nearly 72% reported caffeine consumption. Structural equation modeling showed that caffeine use disorder (CUD) had a significant direct effect on sleep problems and an indirect effect through depressive symptoms, while caffeine use motives did not directly affect sleep disturbance.

Last updated: Aug 13, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score34/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. From caffeine use motives to sleep disturbance: network and structural equation modeling of caffeine use disorder and depression among caffeine consumers.

observational

Islam Dola ST, Najnin F, Amin MB, Sikder MS, Vangi MJ, Naeem J, Rony MJI, Takia MMR, Kamruzzaman M, Sayeed A, Islam MS, Ether ST · Addictive behaviors reports (2026)

Participants: N/A
Duration: Not reported (cross-sectional)
Intervention: None (observational study)
Outcome: Sleep problems (measured via sleep disturbance symptoms), depressive symptoms, caffeine use disorder symptoms
Effect Size: N/A (not reported in abstract)
Population: University students in Bangladesh (mean age 21.76 years, 56.8% male)

Result:

PubMed: 42571332DOI: 10.1016/j.abrep.2026.100729

Mechanism Graph

Caffeine consumption leads to caffeine use disorder symptoms (e.g., impaired control, tolerance, withdrawal)
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Caffeine use disorder symptoms contribute to depressive symptoms
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Depressive symptoms are closely linked to sleep problems (e.g., suicidal ideation, concentration difficulties)
↓
Result: CUD directly and indirectly (via depression) affects sleep problems

Limitations

  • ⚠Cross-sectional design prevents causal inference
  • ⚠Self-reported measures may introduce recall bias
  • ⚠Sample limited to university students, limiting generalizability

Frequently Asked Questions

What is the prevalence of caffeine consumption among Bangladeshi university students?▼

Nearly 72% of the 530 students surveyed reported consuming caffeine.

Does caffeine use disorder directly affect sleep problems?▼

Yes, the study found a significant direct effect of caffeine use disorder on sleep problems.

Do caffeine use motives directly affect sleep disturbance?▼

No, the study found that motives did not directly affect sleep disturbance; their effect was likely mediated through other factors.

What are the key bridge symptoms between caffeine use disorder and depression?▼

Craving and self-reward motives acted as key bridge nodes in the network analysis.

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References

  1. 1.Islam Dola ST, Najnin F, Amin MB, Sikder MS, Vangi MJ, Naeem J, Rony MJI, Takia MMR, Kamruzzaman M, Sayeed A, Islam MS, Ether ST. "From caffeine use motives to sleep disturbance: network and structural equation modeling of caffeine use disorder and depression among caffeine consumers.." Addictive behaviors reports, 2026. PMID: 42571332 DOI: 10.1016/j.abrep.2026.100729
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.