Supplements

Cetaphil Restoraderm Eczema Soothing Moisturizer and Eczema Rapid Relief Cream provide rapid and sustained itch relief in eczema-prone individuals

In a randomized, blinded, split-body study of 33 participants with eczema-prone skin and mild-to-moderate itch, both the eczema moisturizer and eczema cream provided rapid itch relief after a single application, with mean times to relief of 38 seconds and 43 seconds, respectively. Both treatments significantly reduced itch severity from baseline by 98% to 99% at 24 hours (mean NRS 0.03 and 0.09, both P<0.0001).

Last updated: Aug 10, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score44/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Use of an Eczema Moisturizer or Cream Provides Immediate, Sustained Itch Relief in Eczema-Prone Individuals.

rct

Nguyen TQ, Garimella S, Emesiani C, Meckfessel M · Journal of drugs in dermatology : JDD (2026)

Participants: 33
Duration: 24 hours
Intervention: Single application of Cetaphil Restoraderm Eczema Soothing Moisturizer or Cetaphil Restoraderm Eczema Rapid Relief Cream
Outcome: Time to onset of itch relief, itch severity (11-point NRS), participant satisfaction (4-point scale), safety
Effect Size: N/A (reported as mean NRS and percent reduction)
Population: Adults with eczema-prone skin and mild-to-moderate itch (n=33)

Result: In a randomized, blinded, split-body study of 33 participants with eczema-prone skin and mild-to-moderate itch, both the eczema moisturizer and eczema cream provided rapid itch relief after a single application, with mean times to relief of 38 seconds and 43 seconds, respectively. Both treatments significantly reduced itch severity from baseline by 98% to 99% at 24 hours (mean NRS 0.03 and 0.09, both P<0.0001).

PubMed: 42555074DOI: 10.36849/JDD.10110

Mechanism Graph

Moisturizers restore skin barrier function
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Reduced barrier damage may reduce inflammation
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Decreased inflammation reduces itch sensation
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Result: Rapid and sustained itch relief

Limitations

  • ⚠Small sample size (n=33)
  • ⚠Short duration (24 hours) does not assess long-term effects
  • ⚠Industry-sponsored study (Galderma) may introduce bias

Frequently Asked Questions

How quickly do these eczema moisturizers relieve itch?▼

The study found that the eczema moisturizer provided itch relief in a mean of 38 seconds, and the eczema cream in 43 seconds after a single application.

How long does the itch relief last?▼

Both products provided sustained itch relief over 24 hours, with a 98-99% reduction in itch severity from baseline.

Are these products safe for eczema-prone skin?▼

Yes, the study reported that single applications of both products were well tolerated, with no safety concerns mentioned.

What is the study design?▼

It was a randomized, blinded, split-body study where each participant applied both products to different sides of their body, allowing direct comparison.

Products

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References

  1. 1.Nguyen TQ, Garimella S, Emesiani C, Meckfessel M. "Use of an Eczema Moisturizer or Cream Provides Immediate, Sustained Itch Relief in Eczema-Prone Individuals.." Journal of drugs in dermatology : JDD, 2026. PMID: 42555074 DOI: 10.36849/JDD.10110
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.