Supplements

Cheers Restore use is associated with improved next-day subjective well-being after alcohol consumption in healthy adults

In a decentralized observational cohort study of 90 adults, use of the dietary supplement Cheers Restore was associated with statistically significant improvements in next-day mental clarity, physical well-being, energy, and sleep quality compared to alcohol-only nights. Effect sizes were small (Cohen's d = 0.20-0.32). The study was observational and not designed to establish causality.

Last updated: Aug 15, 2026โ€ข0 RCTsโ€ข๐Ÿ“– Read as article โ†’

Evidence Score

Evidence Score38/100
Human RCTโ˜†โ˜†โ˜†โ˜†โ˜†
Meta-analysisโ˜†โ˜†โ˜†โ˜†โ˜†
Mechanismโ˜…โ˜…โ˜…โ˜…โ˜…
Safetyโ˜…โ˜…โ˜…โ˜…โ˜†
Confidencelow

Study Evidence

Study 1. Decentralized Assessment of a Dihydromyricetin- and L-Cysteine-Based Multi-Ingredient Dietary Supplement on Post-Alcohol Recovery: An Observational Cohort Study.

observational

Song S, Wang Y, Atwood L, Shah NR, Jarral RA ยท Nutrients (2026)

Participants: N/A
Duration: Short-term, self-reported follow-up (not specified)
Intervention: Cheers Restore, a multi-ingredient dietary supplement containing dihydromyricetin and L-cysteine, taken as directed by the manufacturer
Outcome: Subjective ratings of energy, mental clarity, physical well-being, and sleep quality (1-10 scale) on the morning after alcohol consumption
Effect Size: Cohen's d = 0.20-0.32
Population: Healthy adults (mean age 44.4 years, 56% female) who consumed alcohol and used the Alethios digital research platform

Result:

PubMed: 42588049DOI: 10.3390/nu18152424

Mechanism Graph

Dihydromyricetin may modulate alcohol metabolism or reduce oxidative stress
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L-cysteine may support acetaldehyde detoxification
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Combined ingredients may reduce next-day hangover symptoms
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Result: Improved subjective well-being and sleep quality

Limitations

  • โš Observational design with self-selected behavioral conditions, limiting causal inference
  • โš Self-reported outcomes and short follow-up period
  • โš Potential selection bias and lack of blinding
  • โš No objective measures of sleep or alcohol consumption

Frequently Asked Questions

What is Cheers Restore?โ–ผ

Cheers Restore is a commercially available dietary supplement containing dihydromyricetin and L-cysteine, marketed to support post-alcohol recovery.

Does Cheers Restore improve sleep quality after drinking?โ–ผ

In this observational study, use of Cheers Restore was associated with a small but statistically significant improvement in self-reported sleep quality (ฮฒ = 0.263, p = 0.002) compared to alcohol-only nights.

Is this study a randomized controlled trial?โ–ผ

No, it is an observational cohort study. The authors recommend a randomized, placebo-controlled trial to establish causality.

What were the main outcomes measured?โ–ผ

The study measured next-day subjective energy, mental clarity, physical well-being, and sleep quality on a 1-10 scale.

Products

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References

  1. 1.Song S, Wang Y, Atwood L, Shah NR, Jarral RA. "Decentralized Assessment of a Dihydromyricetin- and L-Cysteine-Based Multi-Ingredient Dietary Supplement on Post-Alcohol Recovery: An Observational Cohort Study.." Nutrients, 2026. PMID: 42588049 DOI: 10.3390/nu18152424
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.