HormonesMelatonin

Clinicians managing pediatric HSCT inpatients estimate 58% develop sleep issues, and they most commonly implement patient-level interventions like melatonin despite rating external factors like noise as most impactful.

A survey of 111 pediatric HSCT clinicians (prescribers, nurses, psychosocial staff) across the US found they estimate 58% of inpatients develop sleep issues. Although clinicians rated external factors (e.g., noise) as most impactful, they were most likely to implement patient-level interventions such as melatonin. The study highlights the lack of clinical guidelines and the need for research on treatment efficacy and systems-level changes.

Last updated: Aug 13, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. How Clinicians Manage Sleep During Inpatient Hospitalization Following Pediatric Hematopoietic Stem Cell Transplantation.

observational

Chevalier L, Robinson E, Weller E, Klett MK, Daniel LC, Crabtree VM, Mintor R, Blacken R, Tarquini S, Schoettler ML, Fidler AL, Warren EAH, Rosenberg AR, Lehmann LE, Zhou ES · Pediatric blood & cancer (2026)

Participants: N/A
Duration: N/A
Intervention: Survey of clinician-reported management approaches for inpatient sleep disruptions (e.g., melatonin use)
Outcome: Clinician-estimated prevalence of sleep issues (58%), perceived impact of external vs. patient-level factors, and reported intervention choices
Effect Size: N/A
Population: 111 pediatric HSCT medical prescribers, nurses, and psychosocial staff from across the United States

Result:

PubMed: 42527970DOI: 10.1002/1545-5017.70468

Mechanism Graph

Clinicians observe sleep disruptions in pediatric HSCT inpatients
↓
They rate external factors (e.g., noise) as most impactful
↓
Despite this, they most often implement patient-level interventions (e.g., melatonin)
↓
Result: Gap between perceived cause and chosen intervention, indicating need for systems-level changes

Limitations

  • ⚠Survey-based, relying on clinician estimates rather than objective sleep measures
  • ⚠No data on actual efficacy of melatonin or other interventions in this population
  • ⚠Limited generalizability as sample may not represent all pediatric HSCT centers

Frequently Asked Questions

What percentage of pediatric HSCT inpatients develop sleep issues according to clinicians?▼

Clinicians estimated that 58% of inpatients develop sleep issues.

What interventions do clinicians most commonly use for sleep disruptions in pediatric HSCT patients?▼

Clinicians most commonly implement patient-level interventions, such as melatonin.

What did clinicians identify as the most impactful factor for sleep disruptions?▼

Clinicians rated external factors, such as noise, as most impactful.

What does the study recommend for future research?▼

The study recommends assessing the efficacy of commonly delivered treatments and developing systems-level changes to address external sleep barriers.

Products

Affiliate links coming soon. We only recommend products that match the doses and forms used in the cited research.

References

  1. 1.Chevalier L, Robinson E, Weller E, Klett MK, Daniel LC, Crabtree VM, Mintor R, Blacken R, Tarquini S, Schoettler ML, Fidler AL, Warren EAH, Rosenberg AR, Lehmann LE, Zhou ES. "How Clinicians Manage Sleep During Inpatient Hospitalization Following Pediatric Hematopoietic Stem Cell Transplantation.." Pediatric blood & cancer, 2026. PMID: 42527970 DOI: 10.1002/1545-5017.70468
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.