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Digitally delivered interdisciplinary care (ADCompanion) is noninferior to routine care in reducing disease severity in patients with atopic dermatitis

This protocol describes a multicenter randomized noninferiority trial comparing a digital interdisciplinary care concept (ADCompanion) to routine care for atopic dermatitis. The primary endpoint is physician-assessed disease severity (SCORAD) at 6 months, with 603 participants recruited across 7 centers in Germany. Final results are expected in 2026, and the claim of noninferiority is not yet established.

Last updated: Aug 23, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score44/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Remote Interdisciplinary Care for Atopic Dermatitis Using a Digital Care Concept (ADCompanion): Protocol for a Multicenter Randomized Trial.

observational

Dramburg S, Hernandez Toro CJ, Telschow J, Abraham S, Almaci M, Behringer A, Christel S, Cornelius A, Feustel J, Fischer S, Gloeyer I, Günther N, Hagemeister K, Hamelmann E, Harries L, Heratizadeh A, Knappe N, Lämmel S, Moennig E, Neustädter I, Pham C, Rechtien L, Reinhold T, Schnopp C, Schorlemer C, Sollfrank L, Spies S, Stamos K, Sticherling M, Tierno P, Trentmann M, Unterweger MT, Vogelberg C, Winkler H, Worm M, Yoosefi M, Grittner U · JMIR research protocols (2026)

Participants: N/A
Duration: 6 months
Intervention: ADCompanion digital platform with training modules and optional video consultations on skin care, nutrition, and psychosocial support, added to standard therapy
Outcome: Disease severity (SCORAD) at 6 months; secondary outcomes include quality of life, pruritus, psychosocial burden, family well-being, and health care costs
Effect Size: N/A (noninferiority margin not reported in abstract)
Population: Patients with atopic dermatitis (all ages, stratified by age and severity) recruited from 7 centers in Germany

Result:

PubMed: 42623175DOI: 10.2196/88025

Mechanism Graph

Digital platform provides structured patient education modules
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Optional video consultations with interdisciplinary team (skin care, nutrition, psychosocial support)
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Patients engage with educational content and consultations
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Improved self-management and treatment adherence lead to reduced disease severity

Limitations

  • ⚠Results not yet available; protocol only, so noninferiority is not confirmed
  • ⚠Noninferiority design may not detect superiority or small differences in efficacy
  • ⚠Control group includes face-to-face training where available, which may reduce contrast between groups

Frequently Asked Questions

What is the ADCompanion intervention?▼

ADCompanion is a digital platform providing structured training modules and optional video consultations on skin care, nutrition, and psychosocial support, added to standard therapy for atopic dermatitis.

What is the primary outcome of the trial?▼

The primary outcome is physician-assessed disease severity measured by the Scoring Atopic Dermatitis Index (SCORAD) at 6 months.

How many participants are included?▼

The trial recruited 603 participants across 7 centers in Germany.

When will the results be available?▼

Data collection was finalized in June 2025, and final results are expected to be published in 2026.

Products

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References

  1. 1.Dramburg S, Hernandez Toro CJ, Telschow J, Abraham S, Almaci M, Behringer A, Christel S, Cornelius A, Feustel J, Fischer S, Gloeyer I, Günther N, Hagemeister K, Hamelmann E, Harries L, Heratizadeh A, Knappe N, Lämmel S, Moennig E, Neustädter I, Pham C, Rechtien L, Reinhold T, Schnopp C, Schorlemer C, Sollfrank L, Spies S, Stamos K, Sticherling M, Tierno P, Trentmann M, Unterweger MT, Vogelberg C, Winkler H, Worm M, Yoosefi M, Grittner U. "Remote Interdisciplinary Care for Atopic Dermatitis Using a Digital Care Concept (ADCompanion): Protocol for a Multicenter Randomized Trial.." JMIR research protocols, 2026. PMID: 42623175 DOI: 10.2196/88025
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.