Supplements

ETAS reduces wake time after sleep onset in healthy adults dissatisfied with their sleep

In a randomized, placebo-controlled, double-blind crossover study, 14-day intake of ETAS (300 mg/day as ETAS50) did not significantly change the proportion of N3 sleep but significantly reduced wake time after sleep onset (WASO) and total time of N1 sleep. It also improved AIS scores for total score, awakenings during the night, and daytime functioning. Post-hoc analysis showed significant reductions in WASO for those with high baseline WASO and improved sleep efficiency in those with low baseline sleep efficiency.

Last updated: Aug 13, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. ETAS reduces wake time after sleep onset in healthy adults who are dissatisfied with their sleep: A randomized, placebo-controlled, double-blind crossover study.

observational

Misu M, Goto K, Takanari J · Sleep medicine: X (2026)

Participants: N/A
Duration: 14 days intervention, 14-day washout
Intervention: ETAS (standardized extract of Asparagus officinalis stem) 300 mg/day as ETAS50 for 14 days
Outcome: Proportion of N3 sleep (primary), WASO, N1 time, sleep efficiency, AIS-J scores
Effect Size: N/A
Population: 38 healthy adults with sleep dissatisfaction

Result:

PubMed: 42571331DOI: 10.1016/j.sleepx.2026.100196

Mechanism Graph

ETAS intake over 14 days
↓
Modulation of sleep architecture
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Reduction in wake time after sleep onset and N1 sleep
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Improved subjective sleep quality and daytime functioning

Limitations

  • ⚠No significant effect on primary endpoint (N3 proportion)
  • ⚠Post-hoc subgroup analyses were not pre-specified, increasing risk of type I error
  • ⚠Short intervention period (14 days) and small sample size

Frequently Asked Questions

What is ETAS?▼

ETAS is a standardized extract of Asparagus officinalis stem, studied for its potential to improve sleep quality.

Did ETAS improve deep sleep (N3)?▼

No, the study found no statistically significant difference in the proportion of N3 sleep after 14 days of ETAS intake.

What sleep parameters did ETAS improve?▼

ETAS significantly reduced wake time after sleep onset (WASO) and total time of N1 sleep, and improved AIS scores for total score, awakenings during the night, and daytime functioning.

Who might benefit most from ETAS?▼

Post-hoc analysis suggests that individuals with high baseline WASO may see significant reductions in WASO, and those with low sleep efficiency may see improvements in sleep efficiency.

Products

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References

  1. 1.Misu M, Goto K, Takanari J. "ETAS reduces wake time after sleep onset in healthy adults who are dissatisfied with their sleep: A randomized, placebo-controlled, double-blind crossover study.." Sleep medicine: X, 2026. PMID: 42571331 DOI: 10.1016/j.sleepx.2026.100196
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.