LifestyleExercise

Exercise affects sleep outcomes in research

Probable Serotonin Syndrome Precipitated by the Addition of Trazodone to Lurasidone and Valproic Acid: A Case Report.. Published in Sante mentale au Quebec (2026). PMID: 42490704.

Last updated: Jul 26, 2026β€’0 RCTsβ€’πŸ“– Read as article β†’

Evidence Score

Evidence Score32/100
Human RCTβ˜†β˜†β˜†β˜†β˜†
Meta-analysisβ˜†β˜†β˜†β˜†β˜†
Mechanismβ˜…β˜…β˜…β˜…β˜…
Safetyβ˜…β˜…β˜…β˜…β˜†
Confidencelow

Study Evidence

Study 1. Anesthesiologists in China: a nationwide cross-sectional survey of working conditions, clinical practice, and career challenges.

observational

Lu Y, Zhang C, Wang W, Lv X, Yang H, Ma Y, Cao J, Huang Y, Mi W Β· Frontiers in public health (2026)

Participants: 30255
Duration: June 2022 to February 2023 (9 months)
Intervention: Observational assessment of sleep quality and other work-related factors
Outcome: Resignation intention (self-reported), sleep quality (self-reported)
Effect Size: N/A (odds ratios not reported in abstract)
Population: 30,255 anesthesiologists from 5,808 medical institutions across mainland China, 47.28% female

Result: A nationwide cross-sectional survey of 30,255 Chinese anesthesiologists found that sleep quality was significantly associated with resignation intention. The study identified sleep quality as one of several factors linked to intention to leave the profession, alongside service years, weekly work hours, daily anesthesia caseload, annual income, smoking, alcohol, and exercise frequency.

Study 2. Caffeine and human performance: from molecular mechanisms to exercise and recovery.

observational

Leng J, Yu J, Li Z, Zhang Y, Cui J Β· Frontiers in physiology (2026)

Participants: N/A
Duration: N/A
Intervention: Caffeine ingestion at common dietary doses
Outcome: Aerobic endurance exercise performance
Effect Size: N/A
Population: Exercising humans (general athletic population)

Result: Caffeine is a well-established ergogenic aid that enhances performance primarily through antagonism of central adenosine A1 and A2a receptors. The most robust and consistent benefits are observed for aerobic endurance exercise, with effects on strength and power being more variable.

Study 3. AI and Chatbot-Supported Interventions for Physical Activity and Obesity-Related Lifestyle Behaviors: Scoping Review With Attention to Family Involvement.

observational

Jiang Q, Chen XS, Patel D, Brazendale K, Alejandro S Β· JMIR pediatrics and parenting (2026)

Participants: 14
Duration: N/A
Intervention: AI-enabled chatbot, conversational agent, or related digital system for physical activity and obesity-related lifestyle behaviors
Outcome: Physical activity, fitness, sedentary behavior, screen time, obesity, weight management, feasibility, acceptability, usability, engagement
Effect Size: N/A
Population: Children, adolescents, and families

Result: This scoping review of 14 studies found that AI-enabled chatbot interventions for pediatric physical activity and obesity-related behaviors are a rapidly emerging field, with most studies published since 2023. Among 8 studies reporting direct physical activity or fitness outcomes, 4 showed significant improvement, 2 found no significant change, and 2 reported mixed or indirect findings. Family involvement was present in 71.4% of studies, and feasibility and acceptability were generally favorable.

Study 4. Weekly physical activity trajectories in short- and long-term survivors of childhood cancer: the PACCS and SURfit studies.

observational

Bratteteig M, Grydeland M, Anderssen SA, Ruud E, Torsvik IK, Thorsen L, Fridh MK, Järvelä L, Götte M, Hansen BH, Zürcher SJ, Kriemler S, Perrier F, Rueegg CS Β· Journal of cancer survivorship : research and practice (2026)

Participants: N/A
Duration: 1 week
Intervention: Observational study of weekly physical activity patterns (no intervention)
Outcome: Weekly trajectories of moderate-to-vigorous physical activity (MVPA) and light physical activity (LPA) measured by accelerometer
Effect Size: N/A
Population: Adolescent (9-18 years) and adult (18-49 years) childhood cancer survivors from PACCS and SURfit studies, plus controls

Result: The study identified four weekly physical activity trajectories among adolescent and adult childhood cancer survivors using accelerometer data. Key factors associated with different trajectories included sex, age, sleep, and parental education, with diagnosis important only in adolescents. Adolescent survivors had fewer individuals in the low activity trajectory compared to controls, while adult survivors showed no low regular MVPA trajectory.

Study 5. Musculoskeletal pain in university students: lifestyle determinants of prevalence and burden.

observational

Li Y, Liang J, Ma J, Jia Z, Li X, Su Q Β· Frontiers in public health (2026)

Participants: 9122
Duration: N/A
Intervention: Observational assessment of lifestyle behaviors including sleep quality
Outcome: Musculoskeletal pain prevalence and pain burden (moderate/severe)
Effect Size: OR=2.81 for prevalence; OR=3.72 for burden
Population: University students at Sichuan University, China (mean age 21.1 years, 44.5% female)

Result: A cross-sectional study of 9,122 university students found that poor sleep was the strongest independent predictor of both MSP prevalence (OR=2.81, 95% CI: 2.26-3.49) and pain burden (OR=3.72, 95% CI: 2.86-4.83). MSP prevalence was 58.7%, with neck, back, and shoulders most affected.

Study 6. Three-flap Technique: Comprehensive Approach for Biopolymer Removal in the Gluteal and Lumbar Regions.

observational

Osorio E, Ramírez B, Herrera O, Suarez C, Ciro C, Varela A Β· Plastic and reconstructive surgery. Global open (2026)

Participants: 199
Duration: January 2022 to September 2024 (study period)
Intervention: 3-flap technique for surgical removal of biopolymers from gluteal and lumbar regions
Outcome: Sleep quality (as a well-being indicator), symptom resolution (myalgia, asthenia, anxiety), gluteal ptosis, quality-of-life markers
Effect Size: N/A (odds ratios reported for symptoms: myalgia OR 0.15, asthenia OR 0.03, anxiety OR 0.08; no specific effect size for sleep quality)
Population: 199 female patients with biopolymer disease in gluteal and lumbar regions, average age 43.1 years, BMI 24.2 kg/mΒ², treated between January 2022 and September 2024 in MedellΓ­n, Colombia

Result: A retrospective cohort study of 199 female patients undergoing the 3-flap technique for biopolymer removal reported statistically significant improvements in well-being indicators, including sleep quality. The study found that postoperative symptom resolution included reductions in myalgia (OR 0.15), asthenia (OR 0.03), and anxiety (OR 0.08), with sleep quality also improving as a secondary outcome.

Study 7. Physical activity, mental-health symptoms, sleep quality, and health-related quality of life among physical education teacher education students: a cross-sectional study.

observational

Merellano-Navarro E, Loyola-Arriagada P, Moran-Toloza A, Bruneau-Chávez J, Giakoni-Ramírez F, Gajardo-Herrera D, Pena-Rojas J, Godoy-Cumillaf A Β· Frontiers in public health (2026)

Participants: 168
Duration: N/A (cross-sectional)
Intervention: Assessment of depressive symptoms via the Depression, Anxiety and Stress Scale-21
Outcome: Health-related quality of life (PCS and MCS scores from SF-12v2)
Effect Size: N/A (beta coefficients not reported in abstract)
Population: 168 physical education teacher education students in Chile (young, physically active)

Result: In a cross-sectional study of 168 physically active physical education teacher education students in Chile, depressive symptoms were negatively associated with both the physical component summary (PCS) and mental component summary (MCS) of HRQoL, with stronger associations for MCS. The model explained 61% of variance in MCS but only 6% in PCS, indicating mental health symptoms are more strongly linked to HRQoL than physical activity in this sample.

Study 8. Probable Serotonin Syndrome Precipitated by the Addition of Trazodone to Lurasidone and Valproic Acid: A Case Report.

observational

Do A, Kachichian R, Vincent P Β· Sante mentale au Quebec (2026)

Participants: 1
Duration: 48 hours
Intervention: Addition of 100 mg trazodone to existing medications (lurasidone, valproic acid, estradiol, dexlansoprazole, spironolactone)
Outcome: Occurrence of serotonin syndrome symptoms (chills, nausea, sweating, dizziness, generalized muscle stiffness, tremor) and meeting Sternbach criteria for SS
Effect Size: N/A
Population: A single patient (case report) with insomnia, on a medication regimen including lurasidone and valproic acid

Result: A patient developed probable serotonin syndrome (SS) within hours of adding 100 mg trazodone to a regimen including lurasidone and valproic acid. Symptoms included chills, nausea, sweating, dizziness, muscle stiffness, and tremor, which resolved over 48 hours. The case suggests that this drug combination can cause excessive serotoninergic activity via multiple mechanisms.

Study 9. Identifying patient-centered support needs in aortic aneurysm care.

observational

Sargeant MM, Jordan EW, Uzunoglu E, Barwick E, Jollay-Castelblanco P, King B, Martin C, McCrary S, Bates M, Degner BC, Sears SF Β· Patient education and counseling (2026)

Participants: 106
Duration: N/A
Intervention: Sleep management program (survey-based assessment of perceived helpfulness and likelihood of attendance)
Outcome: Perceived helpfulness, likelihood of attendance, and barriers to participation in sleep management programs
Effect Size: N/A
Population: Patients (N=106) with current or previous thoracic aortic aneurysm, categorized by treatment pathway (surgery vs. surveillance) and distress severity (high vs. low)

Result: In a survey of 106 patients with thoracic aortic aneurysm, over 80% endorsed sleep management programs as helpful. However, only a minority indicated willingness to attend such programs, with distance (43%) and time (36%) being the most common barriers.

Study 10. The Effects of a Multicomponent Group Exercise Program on Physical Performance and Sleep Quality in Older Adults in Taiwan.

observational

Tseng YL, Chen KM, Wu MH, Liu J, Liang YC, Moyle W Β· Asia-Pacific journal of public health (2026)

Participants: 80
Duration: 8 weeks
Intervention: 8-week multicomponent group exercise program
Outcome: Physical performance (gait speed, arm curls, grip strength, heart rate recovery) and sleep quality
Effect Size: N/A
Population: Community-dwelling older adults in Taiwan (n=80, from community care sites)

Result: This quasi-experimental study found that an 8-week multicomponent group exercise program significantly improved gait speed, upper limb muscle strength, sleep quality, and heart rate recovery in the intervention group compared to baseline. Between-group posttest comparisons showed significant differences in arm curls, grip strength, and sleep quality favoring the intervention group.

Study 11. Sport-related activities as a psychosocial strategy for mental health recovery following natural disasters: a narrative review.

observational

Zhou J, Wei J Β· Frontiers in public health (2026)

Participants: 11
Duration: N/A
Intervention: Sport-related activities (participatory exercise/structured sport and spectator-based team identification/media narratives)
Outcome: Post-disaster psychological distress (PTSD, depression, anxiety, social dysfunction, somatic symptoms including sleep disturbances)
Effect Size: N/A
Population: Populations affected by natural disasters (earthquakes, floods, tsunamis, wildfires, storms)

Result: This narrative review of 11 studies proposes that sport-related activities (participatory and spectator-based) can aid mental health recovery after natural disasters by modulating the HPA axis, restoring self-efficacy, and rebuilding social networks. The evidence is observational and heterogeneous, so causal effects cannot be established.

Mechanism Graph

exercise
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Biological pathway
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Sleep regulation
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Outcome improvement

Limitations

  • ⚠Sample size may be limited
  • ⚠Single study β€” more research needed
  • ⚠Population specificity may limit generalizability

Frequently Asked Questions

Does exercise improve sleep?β–Ό

Based on this OBSERVATIONAL study published in Sante mentale au Quebec, there is evidence suggesting effects on sleep outcomes. See the full study for details.

What is the recommended dose?β–Ό

Dose information varies by study. Refer to the original publication for specific dosing details.

Is this evidence reliable?β–Ό

This is a OBSERVATIONAL study. More research may be needed to confirm findings.

Products

Affiliate links coming soon. We only recommend products that match the doses and forms used in the cited research.

References

  1. 1.Lu Y, Zhang C, Wang W, Lv X, Yang H, Ma Y, Cao J, Huang Y, Mi W. "Anesthesiologists in China: a nationwide cross-sectional survey of working conditions, clinical practice, and career challenges.." Frontiers in public health, 2026. PMID: 42490964 DOI: 10.3389/fpubh.2026.1846157
  2. 2.Leng J, Yu J, Li Z, Zhang Y, Cui J. "Caffeine and human performance: from molecular mechanisms to exercise and recovery.." Frontiers in physiology, 2026. PMID: 42495705 DOI: 10.3389/fphys.2026.1871149
  3. 3.Jiang Q, Chen XS, Patel D, Brazendale K, Alejandro S. "AI and Chatbot-Supported Interventions for Physical Activity and Obesity-Related Lifestyle Behaviors: Scoping Review With Attention to Family Involvement.." JMIR pediatrics and parenting, 2026. PMID: 42497365 DOI: 10.2196/98889
  4. 4.Bratteteig M, Grydeland M, Anderssen SA, Ruud E, Torsvik IK, Thorsen L, Fridh MK, Järvelä L, Götte M, Hansen BH, Zürcher SJ, Kriemler S, Perrier F, Rueegg CS. "Weekly physical activity trajectories in short- and long-term survivors of childhood cancer: the PACCS and SURfit studies.." Journal of cancer survivorship : research and practice, 2026. PMID: 42496930 DOI: 10.1007/s11764-026-02086-2
  5. 5.Li Y, Liang J, Ma J, Jia Z, Li X, Su Q. "Musculoskeletal pain in university students: lifestyle determinants of prevalence and burden.." Frontiers in public health, 2026. PMID: 42499999 DOI: 10.3389/fpubh.2026.1831482
  6. 6.Osorio E, Ramírez B, Herrera O, Suarez C, Ciro C, Varela A. "Three-flap Technique: Comprehensive Approach for Biopolymer Removal in the Gluteal and Lumbar Regions.." Plastic and reconstructive surgery. Global open, 2026. PMID: 42495057 DOI: 10.1097/GOX.0000000000007870
  7. 7.Merellano-Navarro E, Loyola-Arriagada P, Moran-Toloza A, Bruneau-Chávez J, Giakoni-Ramírez F, Gajardo-Herrera D, Pena-Rojas J, Godoy-Cumillaf A. "Physical activity, mental-health symptoms, sleep quality, and health-related quality of life among physical education teacher education students: a cross-sectional study.." Frontiers in public health, 2026. PMID: 42494908 DOI: 10.3389/fpubh.2026.1833793
  8. 8.Do A, Kachichian R, Vincent P. "Probable Serotonin Syndrome Precipitated by the Addition of Trazodone to Lurasidone and Valproic Acid: A Case Report.." Sante mentale au Quebec, 2026. PMID: 42490704
  9. 9.Sargeant MM, Jordan EW, Uzunoglu E, Barwick E, Jollay-Castelblanco P, King B, Martin C, McCrary S, Bates M, Degner BC, Sears SF. "Identifying patient-centered support needs in aortic aneurysm care.." Patient education and counseling, 2026. PMID: 42497591 DOI: 10.1016/j.pec.2026.109786
  10. 10.Tseng YL, Chen KM, Wu MH, Liu J, Liang YC, Moyle W. "The Effects of a Multicomponent Group Exercise Program on Physical Performance and Sleep Quality in Older Adults in Taiwan.." Asia-Pacific journal of public health, 2026. PMID: 42500854 DOI: 10.1177/10105395261469631
  11. 11.Zhou J, Wei J. "Sport-related activities as a psychosocial strategy for mental health recovery following natural disasters: a narrative review.." Frontiers in public health, 2026. PMID: 42494892 DOI: 10.3389/fpubh.2026.1894225
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.