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Exogenous nucleotides may improve sleep quality in older adults

In a randomized controlled trial of 122 adults aged 60-70, nearly half of participants had room for improvement in sleep quality at baseline. The study will evaluate changes in sleep quality from baseline to 4 months as part of a comprehensive geriatric health assessment, but results are not yet reported.

Last updated: Jul 7, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs): Rationale, Design, and Baseline Characteristics from a Randomized Controlled Trial in Older Adults.

observational

Wang S, Song L, Fan R, Chen Q, You M, Cai M, Wu Y, Li Y, Xu M · Nutrients (2024)

Participants: N/A
Duration: 4 months
Intervention: Exogenous nucleotide supplement (NTs) administered daily for 4 months
Outcome: Sleep quality (measured as part of geriatric health assessment)
Effect Size: N/A
Population: Community-dwelling older adults aged 60-70 years, predominantly female (67.21%), with pre-frailty and at least one chronic condition

Result:

PubMed: 38732590DOI: 10.3390/nu16091343

Mechanism Graph

Nucleotides are involved in cellular processes
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May influence aging-related pathways
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Could improve sleep via anti-aging effects
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Result: potential improvement in sleep quality

Limitations

  • ⚠Results are not yet reported; only baseline characteristics are available
  • ⚠Sleep quality was a secondary outcome, not the primary focus
  • ⚠Dosage of nucleotides not specified in abstract

Frequently Asked Questions

What is the TALENTs trial?▼

TALENTs is a randomized, double-blinded, placebo-controlled trial evaluating exogenous nucleotides as an anti-aging supplement in adults aged 60-70.

How was sleep quality measured in this study?▼

Sleep quality was assessed as part of a comprehensive geriatric health assessment, but specific instruments are not detailed in the abstract.

What were the baseline sleep characteristics of participants?▼

Nearly half of participants had room for improvement in sleep quality at baseline, though mean scores for related measures were within normal range.

Is there evidence that nucleotides improve sleep?▼

This trial aims to test that, but results are not yet available; the abstract only reports baseline data.

Products

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References

  1. 1.Wang S, Song L, Fan R, Chen Q, You M, Cai M, Wu Y, Li Y, Xu M. "Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs): Rationale, Design, and Baseline Characteristics from a Randomized Controlled Trial in Older Adults.." Nutrients, 2024. PMID: 38732590 DOI: 10.3390/nu16091343
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.