Amino AcidsGlycine

Glycine affects sleep outcomes in research

Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.. Published in Journal of ethnopharmacology (2023). PMID: 37517566.

Last updated: Jul 7, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score24/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.

observational

Wang S, Liu L, Liang S, Yang J, Zhang Y, Liu X · Journal of ethnopharmacology (2023)

Participants: N/A
Duration: 21 days
Intervention: Oral administration of Banxia Shumi Decoction (BXSMD) for 21 days
Outcome: mRNA and protein expressions of ESR1 and ESR2 in hypothalamus and hippocampus; sleep-wake activity (open field test); neurotransmitter levels (5-HT, DA, NE, GABA, Glu, MT)
Effect Size: N/A
Population: Female mice with chronic sleep deprivation (CSD) induced by platform water environment for 21 days

Result:

PubMed: 37517566DOI: 10.1016/j.jep.2023.116973

Mechanism Graph

glycine
↓
Biological pathway
↓
Sleep regulation
↓
Outcome improvement

Limitations

  • ⚠Sample size may be limited
  • ⚠Single study — more research needed
  • ⚠Population specificity may limit generalizability

Frequently Asked Questions

Does glycine improve sleep?▼

Based on this ANIMAL study published in Journal of ethnopharmacology, there is evidence suggesting effects on sleep outcomes. See the full study for details.

What is the recommended dose?▼

Dose information varies by study. Refer to the original publication for specific dosing details.

Is this evidence reliable?▼

This is a ANIMAL study. More research may be needed to confirm findings.

Products

Affiliate links coming soon. We only recommend products that match the doses and forms used in the cited research.

References

  1. 1.Wang S, Liu L, Liang S, Yang J, Zhang Y, Liu X. "Effects of BXSMD on ESR1 and ESR2 expression in CSD female mice.." Journal of ethnopharmacology, 2023. PMID: 37517566 DOI: 10.1016/j.jep.2023.116973
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.