Supplements

Golimumab reduces disease activity and improves quality of life in patients with axial spondyloarthritis

Golimumab, an anti-TNF-alpha antibody, is effective in reducing disease activity, back pain, sleep disruption, and fatigue in axial spondyloarthritis, while improving quality of life and work productivity. Real-world studies and post hoc analyses support these benefits, with a favorable safety profile consistent with other TNF inhibitors.

Last updated: Aug 13, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score44/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Golimumab for the Treatment of Axial Spondyloarthritis: Integrating Clinical Outcomes with Real-World Patient Benefits.

observational

Deodhar A, Kim TJ, Navarro-Compán V, Fonseca S, Antunes J, Singh A, Milek R, Wu J, Ramiro S · Advances in therapy (2026)

Participants: N/A
Duration: Not specified
Intervention: Golimumab (anti-TNF-alpha monoclonal antibody) administered as approved treatment for axial spondyloarthritis
Outcome: Disease activity, back pain, sleep disruption, fatigue, quality of life, work productivity, safety
Effect Size: N/A (not reported in abstract)
Population: Patients with axial spondyloarthritis (including those from pivotal RCTs and real-world studies)

Result:

PubMed: 42573952DOI: 10.1007/s12325-026-03742-w

Mechanism Graph

Golimumab binds to and inhibits tumor necrosis factor alpha (TNF-alpha)
↓
Reduction of pro-inflammatory cytokine activity
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Decreased inflammation in sacroiliac joints, spine, and entheses
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Reduced pain, fatigue, sleep disruption, and improved function and quality of life

Limitations

  • ⚠Narrative review, not a systematic review or meta-analysis
  • ⚠Abstract does not provide specific effect sizes or statistical significance values
  • ⚠Real-world data may be subject to selection bias and confounding

Frequently Asked Questions

What is golimumab used for?▼

Golimumab is used for the treatment of axial spondyloarthritis, an inflammatory disease affecting the spine and sacroiliac joints.

Does golimumab improve sleep disruption in axial spondyloarthritis?▼

Yes, according to the review, golimumab decreased sleep disruption in patients with axial spondyloarthritis.

What are the common side effects of golimumab?▼

The safety profile is favorable, with adverse events consistent with other TNF-alpha inhibitors, but specific side effects are not detailed in the abstract.

How does golimumab work?▼

Golimumab inhibits tumor necrosis factor alpha, a pro-inflammatory cytokine involved in the pathogenesis of axial spondyloarthritis.

Products

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References

  1. 1.Deodhar A, Kim TJ, Navarro-Compán V, Fonseca S, Antunes J, Singh A, Milek R, Wu J, Ramiro S. "Golimumab for the Treatment of Axial Spondyloarthritis: Integrating Clinical Outcomes with Real-World Patient Benefits.." Advances in therapy, 2026. PMID: 42573952 DOI: 10.1007/s12325-026-03742-w
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.