Supplements

Hericium erinaceus improves symptoms of sleep disorders

This systematic review found that Hericium erinaceus (Lion's Mane mushroom) supplementation reduced symptoms of sleep disorders in human and animal studies. The review included five randomized controlled trials and three pilot clinical trials, though specific sleep-related effect sizes were not reported.

Last updated: Aug 26, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review.

observational

Menon A, Jalal A, Arshad Z, Nawaz FA, Kashyap R · Frontiers in nutrition (2025)

Participants: N/A
Duration: N/A
Intervention: Hericium erinaceus supplementation (various forms, including mycelium extracts)
Outcome: Symptoms of sleep disorders
Effect Size: N/A
Population: Participants with and without dementia, as well as animal models

Result:

PubMed: 40959699DOI: 10.3389/fnut.2025.1641246

Mechanism Graph

Enhances pro-BDNF and BDNF production
↓
Promotes hippocampal neurogenesis
↓
Improves behavior and reduces symptoms of depression and anxiety
↓
Reduces symptoms of sleep disorders

Limitations

  • ⚠The review includes only five RCTs and three PCTs, limiting generalizability
  • ⚠Specific sleep-related effect sizes and doses were not reported in the abstract

Frequently Asked Questions

What is Hericium erinaceus?▼

Hericium erinaceus, also known as Lion's Mane mushroom, is an edible medicinal fungus with bioactive compounds that may support brain health.

How does Hericium erinaceus improve sleep?▼

It may improve sleep by enhancing BDNF production, promoting hippocampal neurogenesis, and reducing symptoms of depression and anxiety.

What are the side effects of Hericium erinaceus?▼

Potential side effects include stomach discomfort, headache, and allergic reactions, though these are commonly unreported.

Is Hericium erinaceus effective for sleep disorders?▼

The systematic review suggests it reduces symptoms of sleep disorders, but more research is needed to confirm specific effects and dosages.

Products

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References

  1. 1.Menon A, Jalal A, Arshad Z, Nawaz FA, Kashyap R. "Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review.." Frontiers in nutrition, 2025. PMID: 40959699 DOI: 10.3389/fnut.2025.1641246
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.