HormonesMelatonin

Melatonin alleviates polycystic ovary syndrome, premature ovarian insufficiency, ovarian injury, and age-related ovarian function decline

This review establishes an integrated mechanistic model in which oxidative stress, mitochondrial dysfunction, inflammatory responses, and autophagic imbalance contribute to ovarian disorders, while melatonin acts as a pleiotropic regulator counteracting these pathways. The paper reports that melatonin alleviates PCOS, POI, ovarian injury, and age-related ovarian function decline, but no specific effect sizes or sample sizes are provided.

Last updated: Jul 8, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Melatonin in ovarian function and dysfunction: Molecular mechanisms and therapeutic potential.

observational

Zhao X, Zhang Y, Ding K, Qiu Z, Wang Y, Yu X · Journal of ovarian research (2026)

Participants: N/A
Duration: N/A
Intervention: Melatonin (MT) administration
Outcome: Alleviation of PCOS, POI, ovarian injury, and age-related ovarian function decline
Effect Size: N/A
Population: Ovarian disorder patients (PCOS, POI, ovarian injury, age-related decline) and animal models

Result:

PubMed: 42399726DOI: 10.1186/s13048-026-02188-6

Mechanism Graph

Oxidative stress contributes to ovarian disorders
↓
Mitochondrial dysfunction contributes to ovarian disorders
↓
Inflammatory responses and autophagic imbalance contribute to ovarian disorders
↓
Melatonin counteracts these interconnected pathological pathways

Limitations

  • ⚠This is a review paper, not a primary study, so no original experimental data are presented
  • ⚠Optimal dosage, administration regimens, and therapeutic targets remain undetermined

Frequently Asked Questions

What ovarian conditions does melatonin help with?▼

Melatonin alleviates polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI), ovarian injury, and age-related ovarian function decline.

How does melatonin protect ovarian function?▼

Melatonin acts as a pleiotropic regulator that counteracts oxidative stress, mitochondrial dysfunction, inflammatory responses, and autophagic imbalance.

Is melatonin effective against ovarian tumors?▼

The review discusses recent advances regarding the inhibitory effects of melatonin on ovarian tumors, but does not provide specific efficacy data.

What is the recommended dose of melatonin for ovarian disorders?▼

The paper states that further research is needed to determine optimal dosage, so no specific dose is recommended.

Products

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References

  1. 1.Zhao X, Zhang Y, Ding K, Qiu Z, Wang Y, Yu X. "Melatonin in ovarian function and dysfunction: Molecular mechanisms and therapeutic potential.." Journal of ovarian research, 2026. PMID: 42399726 DOI: 10.1186/s13048-026-02188-6
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.