HormonesMelatonin

Melatonin amplitude is positively associated with sleep efficiency in Arctic residents

In 15 Arctic residents, melatonin amplitude showed a significant positive association with sleep efficiency (β = 0.317, p < 0.037, η² = 0.10) after adjusting for photoperiod, while melatonin phase parameters (acrophase or DLMO) had no significant relationship. No seasonal variations in sleep efficiency were observed across winter solstice, spring equinox, and summer solstice.

Last updated: Aug 6, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score34/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Melatonin Amplitude, but Not Phase, Is Associated with Sleep Efficiency in the Arctic.

observational

Gubin DG, Kolomeychuk SN, Petrov IM, Markov AA, Petrova YA, Voronin KA, Mezhakova MS, Boldyreva YV, Shigabaeva AU · Bulletin of experimental biology and medicine (2026)

Participants: N/A
Duration: Across winter solstice, spring equinox, and summer solstice
Intervention: None (observational study of endogenous melatonin rhythm)
Outcome: Sleep efficiency measured by actigraphy
Effect Size: η² = 0.10
Population: 15 Arctic residents

Result:

PubMed: 42507091DOI: 10.1007/s10517-026-06711-z

Mechanism Graph

Melatonin amplitude reflects the strength of circadian signal
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Higher amplitude may enhance synchronization of sleep-wake cycles
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Improved synchronization leads to more consolidated sleep
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Result: Higher sleep efficiency

Limitations

  • ⚠Small sample size (n=15) limits generalizability
  • ⚠Observational design cannot establish causality between melatonin amplitude and sleep efficiency

Frequently Asked Questions

Does melatonin phase affect sleep efficiency in Arctic residents?▼

No, the study found no significant relationship between melatonin phase parameters (acrophase or DLMO) and sleep efficiency (p > 0.3).

What was the effect size of melatonin amplitude on sleep efficiency?▼

The effect size was η² = 0.10, indicating a medium effect explaining 10% of the variance in sleep efficiency.

Did sleep efficiency vary across seasons in this study?▼

No, analysis revealed no significant seasonal variations in sleep efficiency across winter solstice, spring equinox, and summer solstice (p > 0.05).

What intervention does this study suggest for improving sleep?▼

The findings suggest that interventions aimed at augmenting melatonin rhythm amplitude may be effective for improving sleep quality.

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References

  1. 1.Gubin DG, Kolomeychuk SN, Petrov IM, Markov AA, Petrova YA, Voronin KA, Mezhakova MS, Boldyreva YV, Shigabaeva AU. "Melatonin Amplitude, but Not Phase, Is Associated with Sleep Efficiency in the Arctic.." Bulletin of experimental biology and medicine, 2026. PMID: 42507091 DOI: 10.1007/s10517-026-06711-z
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.