Supplements

Migraine subtypes exhibit distinct interictal cognitive event-related potential (CERP) alterations, with migraine without aura showing prolonged N200/P300 latencies and reduced P300 amplitude, while migraine with aura shows the longest latencies, and migraine aura without headache shows increased amplitudes correlated with neuropsychiatric symptoms.

This cross-sectional study compared cognitive event-related potentials (N200, P300) in 173 participants across migraine subtypes and healthy controls. Migraine without aura (MwoA) showed significantly prolonged N200 and P300 latencies and decreased P300 amplitudes compared to controls, while migraine with aura (MwA) had the longest latencies among all subtypes. Migraine aura without headache (MAwH) showed higher N200/P300 amplitudes than MwoA, and these amplitudes correlated positively with anxiety, depression, and insomnia scores.

Last updated: Aug 26, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Interictal cognitive event-related potentials in migraine subtypes: association with neuropsychiatric symptoms.

observational

Waliszewska-Prosół M, Misiak B, Petrušić I, Marschollek K, Budrewicz S · Frontiers in neurology (2026)

Participants: N/A
Duration: Not specified (cross-sectional)
Intervention: No intervention; observational comparison of migraine subtypes (MwoA, MwA, MAwH) versus healthy controls.
Outcome: Cognitive event-related potentials (N200 and P300 latencies and amplitudes), disease burden (MIDAS, HIT-6), insomnia severity (ISI), anxiety and depression (HADS), disease duration.
Effect Size: N/A
Population: 173 participants: 55 with migraine without aura, 40 with migraine with aura, 23 with migraine aura without headache, and 55 healthy controls.

Result:

PubMed: 42591320DOI: 10.3389/fneur.2026.1875362

Mechanism Graph

Migraine subtypes involve distinct interictal neuronal network disturbances affecting cognitive processing.
↓
MwoA shows prolonged N200/P300 latencies and reduced P300 amplitude, indicating altered attention and working memory processing.
↓
MwA shows the longest latencies, suggesting more pronounced cognitive processing delays.
↓
MAwH shows increased amplitudes, which correlate with neuropsychiatric symptoms, suggesting psychological comorbidity modulates neurophysiological responses.

Limitations

  • ⚠Cross-sectional design prevents causal inference.
  • ⚠No correction for multiple comparisons reported in abstract.
  • ⚠Potential confounding by medication use or other comorbidities not fully addressed.
  • ⚠Sample size for MAwH group is relatively small (n=23).

Frequently Asked Questions

What are cognitive event-related potentials (CERP) and why are they used in migraine research?▼

CERP are EEG-based measures of brain electrical activity in response to cognitive tasks, such as the N200 and P300 components, which reflect attention and working memory processing. They are used to assess objective cognitive function in migraine patients, as subjective cognitive decline is common.

Which migraine subtype shows the most severe cognitive ERP alterations?▼

Migraine with aura (MwA) showed the longest N200 and P300 latencies among all subtypes, indicating the most pronounced delays in cognitive processing. However, migraine without aura (MwoA) showed reduced P300 amplitudes, which was not seen in MwA.

How do neuropsychiatric symptoms relate to cognitive ERPs in migraine aura without headache (MAwH)?▼

In the MAwH group, P300 parameters showed strong positive correlations with anxiety, depression, and insomnia scores, suggesting that psychological comorbidities are strongly linked to modulation of neurophysiological responses in this subtype.

Is there a relationship between disease duration and cognitive ERP latencies?▼

Yes, across all migraine subtypes, progressive latency prolongation was associated with longer disease duration, indicating that chronic migraine may lead to cumulative cognitive processing delays.

Products

Affiliate links coming soon. We only recommend products that match the doses and forms used in the cited research.

References

  1. 1.Waliszewska-Prosół M, Misiak B, Petrušić I, Marschollek K, Budrewicz S. "Interictal cognitive event-related potentials in migraine subtypes: association with neuropsychiatric symptoms.." Frontiers in neurology, 2026. PMID: 42591320 DOI: 10.3389/fneur.2026.1875362
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.