Supplements
Modified Sini Powder (MSNP) reduces depressive symptoms in postoperative non-small cell lung cancer patients with mild-to-moderate depression
This protocol describes a multicenter, randomized, double-blind, placebo-controlled trial evaluating MSNP for postoperative mild-to-moderate depression in NSCLC patients. The primary outcome is the total effective rate at 6 weeks, defined as a ≥25% reduction in the 17-item Hamilton Depression Rating Scale score from baseline. The study aims to provide robust clinical evidence and explore multi-omics mechanisms.
Evidence Score
Evidence Score44/100
Human RCT
Meta-analysis
Mechanism
Safety
Confidencelow
Study Evidence
Study 1. Modified sini powder for the management of postoperative depression in non-small cell lung cancer patients: a multicenter, randomized, double-blind, placebo-controlled trial protocol.
observationalJin Y, Wang J, Li H, Fan M, Zhang S, Lin B, Mi Y, Gong C, Gu P, Xu K, Zhao B, Lang J, Chen M · Frontiers in pharmacology (2026)
Participants: N/A
Duration: 6 weeks
Intervention: Modified Sini Powder (MSNP) containing intervention vs. placebo control, administered for 6 weeks
Outcome: Total effective rate (≥25% reduction in 17-item Hamilton Depression Rating Scale score), anxiety, sleep quality, fear of cancer recurrence, quality of life, survival
Effect Size: N/A
Population: Postoperative patients with non-small cell lung cancer (NSCLC) and mild-to-moderate depression (n=468, across nine tertiary medical centers)
Result:
Mechanism Graph
MSNP modulates inflammatory cytokines and HPA axis hormones
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Alters neurotransmitter levels and brain-derived neurotrophic factor
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Changes serum metabolomics and gut microbiota profiles
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Result: Multi-target and multi-pathway alleviation of depressive symptoms
Limitations
- ⚠Protocol only; no results yet reported, so efficacy and safety remain unconfirmed
- ⚠Potential placebo effect due to subjective nature of depression rating scales
- ⚠Generalizability limited to Chinese tertiary medical centers and mild-to-moderate depression
Products
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References
- 1.Jin Y, Wang J, Li H, Fan M, Zhang S, Lin B, Mi Y, Gong C, Gu P, Xu K, Zhao B, Lang J, Chen M. "Modified sini powder for the management of postoperative depression in non-small cell lung cancer patients: a multicenter, randomized, double-blind, placebo-controlled trial protocol.." Frontiers in pharmacology, 2026. PMID: 42403716 DOI: 10.3389/fphar.2026.1805554
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.