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Montmorency tart cherry and blueberry juice consumption may improve cardiometabolic outcomes including systolic blood pressure, sleep efficacy, and other indices in healthy individuals.

This protocol describes a 20-day, single-blind, randomized placebo-controlled trial testing the effects of 60 mL/day of Montmorency tart cherry juice or blueberry juice versus a flavored placebo on cardiometabolic outcomes in 45 healthy individuals. Primary outcome is between-group difference in systolic blood pressure from baseline to post-intervention; secondary outcomes include sleep efficacy indices, anthropometric measures, energy expenditure, and psychological wellbeing. The study is registered and approved but results are not yet reported.

Last updated: Aug 26, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Effects of Montmorency Tart Cherry and Blueberry Juice on Cardiometabolic Outcomes in Healthy Individuals: Protocol for a 3-Arm Placebo Randomized Controlled Trial.

observational

Sinclair J, Shadwell G, Dillon S, Allan R, Butters B, Bottoms L · International journal of environmental research and public health (2021)

Participants: N/A
Duration: 20 days
Intervention: 60 mL per day of Montmorency tart cherry juice, blueberry juice, or a cherry/blueberry flavored placebo for 20 days
Outcome: Systolic blood pressure (primary); secondary: anthropometric measures, energy expenditure, substrate oxidation, haematological indices, blood pressure/resting heart rate, psychological wellbeing, and sleep efficacy indices
Effect Size: N/A
Population: 45 healthy individuals (no specific age or health condition detailed in abstract)

Result:

PubMed: 34574679DOI: 10.3390/ijerph18189759

Mechanism Graph

Anthocyanins in Montmorency tart cherries and blueberries are absorbed and metabolized
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Anthocyanins exert antioxidant and anti-inflammatory effects
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These effects may improve endothelial function and reduce oxidative stress
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Result: Potential reduction in systolic blood pressure and improvement in sleep and other cardiometabolic outcomes

Limitations

  • ⚠This is a protocol paper; no actual results are reported, so efficacy cannot be assessed
  • ⚠Small sample size (n=45) may limit generalizability and statistical power
  • ⚠Single-blind design may introduce bias compared to double-blind trials

Frequently Asked Questions

What is the primary outcome of this study?▼

The primary outcome is the between-group difference in systolic blood pressure from baseline to post-intervention after 20 days of juice consumption.

How much juice do participants consume daily?▼

Participants consume 60 mL per day of either Montmorency tart cherry juice, blueberry juice, or a placebo.

Does this study measure sleep outcomes?▼

Yes, sleep efficacy indices are included as a secondary outcome measure.

Is this study completed and published with results?▼

No, this is a protocol paper describing the planned trial; results are not yet available.

Products

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References

  1. 1.Sinclair J, Shadwell G, Dillon S, Allan R, Butters B, Bottoms L. "Effects of Montmorency Tart Cherry and Blueberry Juice on Cardiometabolic Outcomes in Healthy Individuals: Protocol for a 3-Arm Placebo Randomized Controlled Trial.." International journal of environmental research and public health, 2021. PMID: 34574679 DOI: 10.3390/ijerph18189759
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.