Supplements

N-PEP-12 supplementation improves attention, working memory, and mental wellbeing in healthy middle-aged and older adults with subjective cognitive complaints

In a randomized, double-blind, placebo-controlled trial of 276 adults aged 50-75 with subjective cognitive complaints, N-PEP-12 supplementation (45 mg or 90 mg daily) showed a significant time-dependent treatment effect on primary attention outcomes (group-by-visit interaction p=0.003). Exploratory analyses at 90 days showed greater improvements in alertness, attention omissions, memory omissions, and Digit Span scores for both N-PEP-12 groups compared to placebo, with no significant main effect of treatment arm (p=0.133).

Last updated: Aug 28, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score44/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Impact of N-PEP-12 Supplementation on Attentional Performance and Mental Wellbeing in Healthy Adults with Subjective Cognitive Complaints: A Randomized, Placebo-Controlled Trial.

observational

Chira D, Jemna N, Verișezan-Roșu O, Buruiană AM, Strilciuc Ș, Chelaru VF, Pârvu S, Mureșanu DF · Nutrients (2026)

Participants: N/A
Duration: 180 days (with extension phase)
Intervention: N-PEP-12 (peptide-based nutritional supplement) at doses of 45 mg or 90 mg daily
Outcome: Attentional performance (Test of Attentional Performance), working memory (WAIS-IV Digit Span Forward and Backward), perceived stress, mood, sleep quality, and EQ-5D-5L visual analog scale
Effect Size: N/A (not reported in abstract)
Population: Healthy middle-aged and older adults (50-75 years) with subjective cognitive complaints and no clinically significant cognitive impairment

Result:

PubMed: 42654319DOI: 10.3390/nu18162739

Mechanism Graph

N-PEP-12 provides peptide-based nutrients with potential neuroprotective effects
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Supplementation may support neuronal function and synaptic plasticity
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Improved neuronal health may enhance attentional and working memory processes
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Result: Improved attention and working memory performance in adults with SCCs

Limitations

  • ⚠Primary outcome analysis showed no significant main effect of treatment arm (p=0.133), only a time-dependent interaction, indicating the effect is not straightforward
  • ⚠Endpoint-specific improvements at 90 days were exploratory and not corrected for multiple comparisons
  • ⚠Uncontrolled extension phase limits causal inference for the placebo-switch group
  • ⚠Subjective cognitive complaints are self-reported and may not reflect objective cognitive decline

Frequently Asked Questions

What is N-PEP-12?▼

N-PEP-12 is a peptide-based nutritional supplement with potential neuroprotective effects, tested in doses of 45 mg and 90 mg daily.

Who might benefit from N-PEP-12?▼

Healthy middle-aged and older adults (50-75 years) with subjective cognitive complaints, such as memory or attention issues, may see improvements in attention and working memory.

How long does it take to see effects?▼

In this study, improvements were observed at 90 days of supplementation, with assessments also at 30 and 180 days.

Are there any side effects?▼

Adverse events were infrequent and similarly distributed across groups, suggesting good tolerability, though specific side effects were not detailed in the abstract.

Products

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References

  1. 1.Chira D, Jemna N, Verișezan-Roșu O, Buruiană AM, Strilciuc Ș, Chelaru VF, Pârvu S, Mureșanu DF. "Impact of N-PEP-12 Supplementation on Attentional Performance and Mental Wellbeing in Healthy Adults with Subjective Cognitive Complaints: A Randomized, Placebo-Controlled Trial.." Nutrients, 2026. PMID: 42654319 DOI: 10.3390/nu18162739
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.