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Nucleotide supplementation may improve sleep quality in older adults aged 60-70 years

This randomized controlled trial (TALENTs) enrolled 122 community-dwelling adults aged 60-70 years, with nearly half having room for improvement in sleep quality at baseline. The study will evaluate changes in sleep quality from baseline to 4 months as part of a comprehensive geriatric health assessment, comparing a nucleotide intervention group to a placebo control group.

Last updated: Aug 26, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs): Rationale, Design, and Baseline Characteristics from a Randomized Controlled Trial in Older Adults.

observational

Wang S, Song L, Fan R, Chen Q, You M, Cai M, Wu Y, Li Y, Xu M · Nutrients (2024)

Participants: N/A
Duration: 4 months
Intervention: Exogenous nucleotide supplement (NTs) administered daily for 4 months
Outcome: Sleep quality (measured as part of geriatric health assessment)
Effect Size: N/A
Population: Community-dwelling older adults aged 60-70 years, predominantly female (67.21%), with pre-frailty and at least one chronic condition

Result:

PubMed: 38732590DOI: 10.3390/nu16091343

Mechanism Graph

Nucleotides are absorbed and utilized by cells
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They support cellular processes including DNA repair and immune function
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Improved cellular health may reduce inflammation and oxidative stress
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Result: Potential improvement in sleep quality and other aging-related outcomes

Limitations

  • ⚠Baseline sleep quality was not severely impaired (mean scores within normal range), limiting generalizability to clinical insomnia populations
  • ⚠The study is ongoing; only baseline characteristics are reported, so no causal conclusions can yet be drawn
  • ⚠The sample is predominantly female, which may limit generalizability to male older adults

Frequently Asked Questions

What is the TALENTs trial?▼

TALENTs is a randomized, double-blinded, placebo-controlled trial testing whether exogenous nucleotide supplements can act as an anti-aging intervention in older adults aged 60-70 years.

How is sleep quality measured in this study?▼

Sleep quality is assessed as part of a comprehensive geriatric health evaluation, though the specific instrument (e.g., PSQI) is not detailed in the abstract.

What were the baseline sleep characteristics of participants?▼

Nearly half of participants had room for improvement in sleep quality, but mean scores were within the normal range, indicating mild rather than severe sleep issues.

When will results on sleep quality be available?▼

The study measures outcomes at 2 months and 4 months of intervention; results are pending as only baseline data are reported in this paper.

Products

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References

  1. 1.Wang S, Song L, Fan R, Chen Q, You M, Cai M, Wu Y, Li Y, Xu M. "Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs): Rationale, Design, and Baseline Characteristics from a Randomized Controlled Trial in Older Adults.." Nutrients, 2024. PMID: 38732590 DOI: 10.3390/nu16091343
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.