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Nucleotides (NTs) as an anti-aging supplement may improve sleep quality in older adults, but efficacy is not yet established.

The TALENTs trial enrolled 122 adults aged 60-70 years to evaluate nucleotides as an anti-aging supplement. Baseline data showed nearly half of participants had room for improvement in sleep quality, but results on NT effects are pending.

Last updated: Jul 7, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs): Rationale, Design, and Baseline Characteristics from a Randomized Controlled Trial in Older Adults.

observational

Wang S, Song L, Fan R, Chen Q, You M, Cai M, Wu Y, Li Y, Xu M · Nutrients (2024)

Participants: N/A
Duration: 4 months
Intervention: Exogenous nucleotide supplement (NTs) administered daily for 4 months
Outcome: Sleep quality (measured as part of geriatric health assessment)
Effect Size: N/A
Population: Community-dwelling older adults aged 60-70 years, predominantly female (67.21%), with pre-frailty and at least one chronic condition

Result:

PubMed: 38732590DOI: 10.3390/nu16091343

Mechanism Graph

Nucleotides are involved in cellular processes
↓
May influence aging pathways
↓
Potential to improve sleep quality
↓
Result pending from trial

Limitations

  • ⚠Baseline data only; no intervention results reported
  • ⚠Sleep quality was a secondary outcome, not primary
  • ⚠Nearly half of participants had room for improvement, but normal range suggests ceiling effect

Frequently Asked Questions

What is the TALENTs trial about?▼

It is a randomized, double-blinded, placebo-controlled trial testing nucleotides as an anti-aging supplement in older adults aged 60-70.

Does this paper show that nucleotides improve sleep?▼

No, the paper only reports baseline characteristics; sleep quality was measured but results from the intervention are not yet available.

Who were the participants in this study?▼

122 community-dwelling adults aged 60-70, mostly female (67.21%), with pre-frailty and at least one chronic condition.

What outcomes were measured besides sleep?▼

Primary outcomes were leukocyte telomere length and DNA methylation age; secondary outcomes included immunity, inflammation, oxidative stress, physical function, and cognition.

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References

  1. 1.Wang S, Song L, Fan R, Chen Q, You M, Cai M, Wu Y, Li Y, Xu M. "Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs): Rationale, Design, and Baseline Characteristics from a Randomized Controlled Trial in Older Adults.." Nutrients, 2024. PMID: 38732590 DOI: 10.3390/nu16091343
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.