Supplements

Nucleotides supplementation may improve sleep quality in older adults aged 60-70 years

The TALENTs trial is a randomized, double-blinded, placebo-controlled study evaluating nucleotides as an anti-aging supplement in 122 older adults (mean age 65.65 years, 67.21% female). Baseline data showed that nearly half of participants had room for improvement in sleep quality, and sleep quality was measured as a secondary outcome at 2 and 4 months.

Last updated: Jul 7, 2026•1 RCTs•📖 Read as article →

Evidence Score

Evidence Score42/100
Human RCT★★☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs): Rationale, Design, and Baseline Characteristics from a Randomized Controlled Trial in Older Adults.

observational

Wang S, Song L, Fan R, Chen Q, You M, Cai M, Wu Y, Li Y, Xu M · Nutrients (2024)

Participants: N/A
Duration: 4 months
Intervention: Exogenous nucleotide supplement (NTs) administered daily for 4 months
Outcome: Sleep quality (measured as part of geriatric health assessment)
Effect Size: N/A
Population: Community-dwelling older adults aged 60-70 years, predominantly female (67.21%), with pre-frailty and at least one chronic condition

Result:

PubMed: 38732590DOI: 10.3390/nu16091343

Mechanism Graph

Nucleotides are involved in cellular processes
↓
Nucleotides may reduce oxidative stress and inflammation
↓
Improved cellular function may support sleep regulation
↓
Result: Potential improvement in sleep quality

Limitations

  • ⚠Baseline data only; no post-intervention results reported yet
  • ⚠Sleep quality is a secondary outcome, not primary, limiting statistical power for this specific claim
  • ⚠Nearly half of participants had room for improvement, but baseline sleep quality was not severely impaired

Frequently Asked Questions

What is the TALENTs trial?▼

TALENTs is a randomized, double-blinded, placebo-controlled trial testing nucleotides as an anti-aging supplement in adults aged 60-70 years.

How was sleep quality measured in this study?▼

Sleep quality was assessed as part of a comprehensive geriatric health assessment at baseline, 2 months, and 4 months.

Did the study find that nucleotides improve sleep?▼

The abstract reports baseline characteristics only; results on sleep quality changes after intervention are not yet available.

Who were the participants in this trial?▼

122 community-dwelling adults aged 60-70 years, mostly female (67.21%), with pre-frailty and at least one chronic condition.

Products

Affiliate links coming soon. We only recommend products that match the doses and forms used in the cited research.

References

  1. 1.Wang S, Song L, Fan R, Chen Q, You M, Cai M, Wu Y, Li Y, Xu M. "Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs): Rationale, Design, and Baseline Characteristics from a Randomized Controlled Trial in Older Adults.." Nutrients, 2024. PMID: 38732590 DOI: 10.3390/nu16091343
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.