FlavonoidsApigenin

Nurexan contains flavonoids (vitexin, isovitexin, orientin, isoorientin, apigenin) and alkaloids (caffeine, trigonelline) with potential pharmacological relevance for stress and sleep regulation.

Chemical analysis of Nurexan, a multicomponent natural veterinary medicinal product, identified flavonoids such as vitexin (1-2 ng per tablet) and isovitexin (4-11 ng per tablet) along with other compounds from Passiflora incarnata, Avena sativa, and Coffea arabica. These constituents may have anxiolytic and sleep-regulating effects, but their functional roles require further study.

Last updated: Jul 7, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Chemical characterization of Nurexan: composition of a multicomponent natural veterinary medicinal product.

observational

Duller S, Bader M, Uhl O, Wergin M · Frontiers in veterinary science (2026)

Participants: N/A
Duration: N/A
Intervention: Nurexan tablets (veterinary formulation containing Passiflora incarnata, Avena sativa, Coffea arabica, and Zincum isovalerianicum)
Outcome: Chemical composition (flavonoids, alkaloids, caffeine) quantified via UPLC-HR-MS and LC-MS/MS
Effect Size: N/A
Population: Not applicable (chemical analysis of veterinary product; no animal subjects)

Result:

PubMed: 41800299DOI: 10.3389/fvets.2026.1769201

Mechanism Graph

Plant extracts in Nurexan contain flavonoids (e.g., vitexin, isovitexin) and alkaloids (e.g., caffeine, trigonelline)
↓
These compounds are known for calming, anxiolytic, and neuroactive properties
↓
Potential synergistic interactions among ingredients may enhance stress and sleep regulation
↓
Result: Nurexan exhibits a complex chemical profile with possible pharmacological relevance

Limitations

  • ⚠The study only characterized chemical composition; no functional or efficacy testing was performed
  • ⚠Sample size was limited to 3 batches of Nurexan tablets, which may not capture batch variability

Frequently Asked Questions

What is Nurexan used for?▼

Nurexan is a veterinary natural medication used to mitigate stress responses in domestic animals.

What active compounds were found in Nurexan?▼

Key compounds include flavonoids (vitexin, isovitexin, orientin, isoorientin, apigenin) and alkaloids (caffeine, trigonelline), with vitexin at 1-2 ng and isovitexin at 4-11 ng per tablet.

Does this study prove Nurexan works for sleep?▼

No, this study only identified the chemical composition; further studies are needed to determine if these compounds have functional roles in sleep regulation.

What methods were used to analyze Nurexan?▼

Ultra-performance liquid chromatography with high-resolution and tandem mass spectrometry (UPLC-HR-MS, LC-MS/MS) was used for compound screening and quantification.

Products

Affiliate links coming soon. We only recommend products that match the doses and forms used in the cited research.

References

  1. 1.Duller S, Bader M, Uhl O, Wergin M. "Chemical characterization of Nurexan: composition of a multicomponent natural veterinary medicinal product.." Frontiers in veterinary science, 2026. PMID: 41800299 DOI: 10.3389/fvets.2026.1769201
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.