Supplements

Nurexan contains flavonoids with potential pharmacological relevance for stress and sleep regulation

Nurexan, a multicomponent natural veterinary medicinal product, was analyzed using UPLC-HR-MS and LC-MS/MS, revealing a complex chemical profile including flavonoids such as vitexin (1-2 ng per tablet) and isovitexin (4-11 ng per tablet). These compounds, derived from Passiflora incarnata, Avena sativa, and Coffea arabica, may have anxiolytic and neuroactive effects relevant to stress and sleep regulation.

Last updated: Aug 26, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Chemical characterization of Nurexan: composition of a multicomponent natural veterinary medicinal product.

observational

Duller S, Bader M, Uhl O, Wergin M · Frontiers in veterinary science (2026)

Participants: N/A
Duration: N/A
Intervention: Nurexan tablets (veterinary formulation containing Passiflora incarnata, Avena sativa, Coffea arabica, and Zincum isovalerianicum)
Outcome: Chemical composition (flavonoids, alkaloids, caffeine) quantified via UPLC-HR-MS and LC-MS/MS
Effect Size: N/A
Population: Not applicable (chemical analysis of veterinary product; no animal subjects)

Result:

PubMed: 41800299DOI: 10.3389/fvets.2026.1769201

Mechanism Graph

Nurexan contains flavonoids (vitexin, isovitexin, orientin, isoorientin, apigenin) and alkaloids (trigonelline, caffeine)
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These compounds have traditionally been associated with calming, anxiolytic, and neuroactive effects
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Potential synergistic interactions among ingredients may enhance stress and sleep regulation
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Result: Nurexan exhibits a complex composition with potential pharmacological relevance

Limitations

  • ⚠The study only characterized chemical composition; no functional or behavioral assays were performed to confirm effects on stress or sleep
  • ⚠Sample size limited to 3 batches of Nurexan tablets, which may not capture batch-to-batch variability
  • ⚠Quantification was only performed for vitexin and isovitexin; other compounds were not quantified

Frequently Asked Questions

What is Nurexan used for?▼

Nurexan is a veterinary natural medication used to mitigate stress responses in domestic animals.

What are the main active compounds in Nurexan?▼

Key compounds include flavonoids such as vitexin, isovitexin, orientin, isoorientin, and apigenin, as well as the alkaloid trigonelline and low levels of caffeine.

How much vitexin and isovitexin are in each Nurexan tablet?▼

Vitexin is present at 1-2 ng per tablet, and isovitexin at 4-11 ng per tablet.

Does this study prove that Nurexan improves sleep?▼

No, the study only identified chemical constituents; further studies are needed to elucidate their functional roles in stress and sleep regulation.

Products

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References

  1. 1.Duller S, Bader M, Uhl O, Wergin M. "Chemical characterization of Nurexan: composition of a multicomponent natural veterinary medicinal product.." Frontiers in veterinary science, 2026. PMID: 41800299 DOI: 10.3389/fvets.2026.1769201
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.