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Objective sleep parameters are associated with distinct cognitive domains in euthymic bipolar disorder

In 40 euthymic individuals with bipolar disorder, actigraphy-measured sleep parameters were associated with cognitive performance. Longer assumed sleep duration was negatively associated with overall cognitive score (β = -0.38, p = 0.011), longer sleep onset latency was negatively associated with working memory (β = -0.41, p = 0.014) and processing speed (β = -0.38, p = 0.002), and greater wake after sleep onset was negatively associated with verbal fluency (β = -0.39, p = 0.016).

Last updated: Jul 7, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score34/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Objective sleep parameters and cognitive performance in euthymic bipolar disorder: a cross-sectional 21-day actigraphy study.

observational

Libourel C, Charron M, Martinot V, Carminati M, Etain B, Hennion V · International journal of bipolar disorders (2026)

Participants: N/A
Duration: 21 days
Intervention: 21-day actigraphy monitoring of objective sleep parameters
Outcome: Cognitive performance measured by the Screen for Cognitive Impairment in Psychiatry (SCIP) total score and domain scores (delayed verbal learning, working memory, processing speed, verbal fluency)
Effect Size: β = -0.38 for assumed sleep duration and SCIP total score; β = -0.48 for total sleep time and delayed verbal learning
Population: 40 euthymic individuals with bipolar disorder

Result:

PubMed: 42371207DOI: 10.1186/s40345-026-00431-z

Mechanism Graph

Sleep disturbances persist during euthymia in bipolar disorder
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Objective sleep parameters (duration, initiation, continuity) are measured via actigraphy
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These parameters are associated with specific cognitive domains
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Sleep continuity and initiation beyond duration alone correlate with cognitive functioning

Limitations

  • ⚠Exploratory cross-sectional design prevents causal inference
  • ⚠Small sample size (n=40) limits generalizability and statistical power
  • ⚠Results considered hypothesis-generating and require replication in larger longitudinal cohorts

Frequently Asked Questions

What sleep parameters were measured in this study?▼

The study measured sleep duration, sleep onset latency, sleep efficiency, wake time after sleep onset (WASO), and fragmentation index using 21-day actigraphy.

Which cognitive domains were affected by sleep parameters?▼

Assumed sleep duration was linked to overall cognition; total sleep time to delayed verbal learning; sleep onset latency to working memory and processing speed; and WASO to verbal fluency.

Was this a randomized controlled trial?▼

No, this was an exploratory cross-sectional observational study, not an RCT, so causality cannot be established.

What were the main limitations of the study?▼

The main limitations include a small sample size (n=40), cross-sectional design, and the authors note results are hypothesis-generating requiring replication.

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References

  1. 1.Libourel C, Charron M, Martinot V, Carminati M, Etain B, Hennion V. "Objective sleep parameters and cognitive performance in euthymic bipolar disorder: a cross-sectional 21-day actigraphy study.." International journal of bipolar disorders, 2026. PMID: 42371207 DOI: 10.1186/s40345-026-00431-z
Disclaimer: This content is for educational purposes only and is not medical advice. Evidence scores reflect the quality and quantity of available research, not clinical recommendations. Always consult a healthcare professional before starting any supplement or intervention.