Phytochemicals such as resveratrol, epigallocatechin gallate, curcumin, jaceosidin, cucurbitacin, apigenin, and genistein trigger activation or inactivation of ATM in different cancer cells, modulating DNA damage response.
This review summarizes evidence from cell-based studies that various phytochemicals can modulate ATM signaling, a master regulator of DNA double-strand break repair. These compounds either activate or inhibit ATM in different cancer cell lines, potentially influencing cell cycle checkpoints, DNA repair, and apoptosis. The paper highlights the therapeutic potential of targeting ATM to enhance responses to DNA damage-inducing therapies.
Evidence Score
Study Evidence
Study 1. Activation and Inhibition of ATM by Phytochemicals: Awakening and Sleeping the Guardian Angel Naturally.
observationalFarooqi AA, Wu SJ, Chang YT, Tang JY, Li KT, Ismail M, Liaw CC, Li RN, Chang HW · Archivum immunologiae et therapiae experimentalis (2016)
Result:
Mechanism Graph
Limitations
- ⚠The paper is a review and does not present original experimental data or quantitative effect sizes
- ⚠Findings are based on cell-based studies only, with no in vivo or clinical validation
- ⚠Specific doses and mechanisms for each phytochemical are not detailed in the abstract
Frequently Asked Questions
What is ATM and why is it important in cancer therapy?▼
ATM (ataxia telangiectasia mutated) is a master regulator of the DNA double-strand break response. It activates checkpoints and repair pathways, making it a target for enhancing the effects of DNA-damaging cancer treatments.
Which phytochemicals are reported to activate ATM in cancer cells?▼
Resveratrol, epigallocatechin gallate, curcumin, jaceosidin, cucurbitacin, apigenin, and genistein are among the phytochemicals reported to trigger ATM activation in different cancer cells.
Can phytochemicals also inhibit ATM?▼
Yes, the review mentions agents for ATM inactivation, though specific phytochemicals for inhibition are not named in the abstract.
What is the significance of TRAIL signaling in this context?▼
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) signaling is modulated by ATM, and understanding this interplay is important for enhancing cancer cell death in response to DNA damage-inducing therapy.
Products
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References
- 1.Farooqi AA, Wu SJ, Chang YT, Tang JY, Li KT, Ismail M, Liaw CC, Li RN, Chang HW. "Activation and Inhibition of ATM by Phytochemicals: Awakening and Sleeping the Guardian Angel Naturally.." Archivum immunologiae et therapiae experimentalis, 2016. PMID: 26089209 DOI: 10.1007/s00005-015-0346-x