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Polysomnography in systemic mastocytosis patients shows frequent sleep-disordered breathing, REM-related changes, and variable arousal burden, but findings cannot be attributed directly to SM due to overweight/obesity predominance and lack of control group.

In a single-center observational study of nine adult patients with systemic mastocytosis (SM), polysomnography revealed that eight of nine patients met criteria for obstructive sleep apnea (OSA), with five mild and three severe cases. Median AHI was 8.2 events/hour, and all overweight/obese patients had OSA, while the only normal-weight patient did not. Brain fog-like complaints were common (six patients), but excessive daytime sleepiness was present in only two patients.

Last updated: Aug 26, 2026•0 RCTs•📖 Read as article →

Evidence Score

Evidence Score32/100
Human RCT☆☆☆☆☆
Meta-analysis☆☆☆☆☆
Mechanism★★★★★
Safety★★★★☆
Confidencelow

Study Evidence

Study 1. Objective Sleep Assessment in Systemic Mastocytosis: Polysomnographic Findings from a Single-Center Observational Study.

observational

Akten HS, Aykaç Ş, Uludağ B, Tunakan Dalgıç C, Gümüşburun R, İnan S, Okan K, Galata Z, Aslan E, Ay E, Camyar A, Aytaç H, Demir M, Yıldırım O, Bulut G, Ates U, Dizdar Canbaz T, Toksoy Sentürk Mİ, Karaaslan Yetemen S, Sin AZ, Mete Gokmen EN · Journal of clinical medicine (2026)

Participants: N/A
Duration: January 2023 to January 2024 (cross-sectional)
Intervention: No intervention; observational study with overnight laboratory polysomnography after discontinuation of antihistamine therapy for at least seven days.
Outcome: Sleep architecture, sleep continuity, sleep-disordered breathing (AHI), oxygenation, periodic limb movements, arousal burden, Epworth Sleepiness Scale (ESS), and brain fog-like cognitive complaints.
Effect Size: N/A
Population: Nine adult patients with systemic mastocytosis from the Ege University Mastocytosis Database (January 2023–January 2024), median age 50 years, 4 women and 5 men, predominantly overweight/obese (8 of 9 with BMI ≥ 25 kg/m²).

Result:

PubMed: 42590170DOI: 10.3390/jcm15156068

Mechanism Graph

Systemic mastocytosis involves clonal mast cell accumulation and mediator release, potentially affecting sleep regulation.
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Overweight/obesity is a known contributor to sleep-disordered breathing, which was prevalent in this cohort.
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Polysomnography identified OSA in 8 of 9 patients, with median AHI 8.2 events/hour.
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Brain fog-like complaints were reported by 6 patients, but only 2 had ESS > 10, suggesting dissociation between subjective and objective sleepiness.

Limitations

  • ⚠No control group was included, limiting ability to attribute findings to SM.
  • ⚠Small sample size (n=9) and single-center design reduce generalizability.
  • ⚠High prevalence of overweight/obesity confounds the relationship between SM and sleep-disordered breathing.
  • ⚠Antihistamine discontinuation may have influenced symptoms or sleep parameters.

Frequently Asked Questions

What is the most common sleep disorder found in systemic mastocytosis patients?▼

Obstructive sleep apnea (OSA) was the most common sleep disorder, with 8 out of 9 patients meeting PSG criteria, though this was confounded by the high prevalence of overweight/obesity.

Are sleep complaints in systemic mastocytosis due to the disease itself?▼

The study cannot confirm a direct causal link because most patients were overweight or obese and there was no control group. Larger controlled studies with BMI-matched groups are needed.

How common is excessive daytime sleepiness in systemic mastocytosis?▼

Only 2 of 9 patients had excessive daytime sleepiness (ESS > 10), despite 6 patients reporting brain fog-like complaints, indicating a dissociation between subjective and objective sleepiness.

Should systemic mastocytosis patients undergo polysomnography?▼

The authors suggest that objective sleep assessment may be useful in selected patients, particularly those with fatigue, non-restorative sleep, or cognitive complaints, but more research is needed.

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References

  1. 1.Akten HS, Aykaç Ş, Uludağ B, Tunakan Dalgıç C, Gümüşburun R, İnan S, Okan K, Galata Z, Aslan E, Ay E, Camyar A, Aytaç H, Demir M, Yıldırım O, Bulut G, Ates U, Dizdar Canbaz T, Toksoy Sentürk Mİ, Karaaslan Yetemen S, Sin AZ, Mete Gokmen EN. "Objective Sleep Assessment in Systemic Mastocytosis: Polysomnographic Findings from a Single-Center Observational Study.." Journal of clinical medicine, 2026. PMID: 42590170 DOI: 10.3390/jcm15156068
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